Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment

Notch signaling is a conserved pathway crucial for nervous system development. Disruptions in this pathway are linked to neurodevelopmental disorders, neurodegenerative diseases, and brain tumors. genes, major downstream targets of Notch, are commonly used as markers for Notch activation. However, t...

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Veröffentlicht in:	International journal of molecular sciences 2024-08, Vol.25 (17), p.9174
Hauptverfasser:	Chen, Yi-Chieh, Hsieh, Fu-Yu, Chang, Chia-Wei, Sun, Mu-Qun, Cheng, Yi-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Brain cancer Embryos Gene expression Gene Expression Regulation, Developmental Genetic engineering Hybridization Ligands Mutation Nervous system Neurodevelopmental disorders Neurogenesis Neurogenesis - genetics Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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