Fatigue Management in Advanced Prostate Cancer: Real-World Insights From Qualitative Interviews With Patients

•Fatigue is a common symptom of prostate cancer and its treatment.•Patients were interviewed to know their experience of fatigue while on treatment with combination of androgen-deprivation therapy and novel hormonal agents.•Patients define symptoms of fatigue as physical, emotional, and/or mental feeling.•Patients expressed the need for fatigue-management educational materials.•Patients self-reported effective strategies to manage fatigue.•Exercise, naps, rest, and a healthy diet were self-reported as the most effective strategies. Patients with advanced prostate cancer (PC) commonly experience fatigue related to the disease itself and its treatment, which affects their quality of life. There are limited real-world data available on patients’ experiences of fatigue while receiving PC treatment and its management. This was a cross-sectional, noninterventional qualitative study involving individual concept-elicitation interviews with patients in the United States. Patients with advanced PC aged ≥18 years who had experienced fatigue and were on androgen-deprivation therapy in combination with second-generation androgen receptor pathway inhibitors were interviewed and their experiences quantified. Of the 143 patients screened, 13 qualified and 11 completed the interview. Most patients used the term “fatigue” (n = 8) to describe their experiences of tiredness, exhaustion, lack of energy, and weakness. Most patients (n = 8) did not receive any form of educational support from their healthcare providers (HCPs), but some expressed an interest in receiving this support (pamphlets, n = 4; discussion with HCPs, n = 4; online resources, n = 3). Most patients (n = 9) self-discovered fatigue-management strategies over the course of their disease and treatment. Patients found that rigorous exercise (n = 5), regular naps (n = 2), increased rest (n = 3), and a healthy diet (n = 3) were the most effective approaches for managing their fatigue. Tools are needed to support HCPs with counseling patients with PC for effective management of disease- and treatment-related fatigue. Real-world data on patient experiences of fatigue in prostate cancer are scarce. Patients on androgen-deprivation therapy plus androgen receptor pathway inhibitors were interviewed to understand their experiences of fatigue. Rigorous exercise, regular naps, increased rest, and healthy eating were self-reported as most effective strategies for managing fatigue. Tools supporting patient counseling and com