Impact of cathepsin K-induced proteoglycans degradation on dentin collagen

This study aimed to investigate the effects of cathepsin K (catK) on proteoglycans (PGs) and the subsequent impacts on dentin collagen degradation. Demineralized dentin samples were prepared and divided into the following groups: deionized water (DW), 0.1 U/mL chondroitinase ABC (C-ABC), and 1 μM od...

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Veröffentlicht in:	Archives of oral biology 2025-01, Vol.169, p.106091, Article 106091
Hauptverfasser:	Jiang, Neng-wu, Chen, Yi-ying, Lin, Xiu-jiao, Yu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cathepsin K Cathepsin K - metabolism Chondroitin ABC Lyase - metabolism Chondroitin ABC Lyase - pharmacology Collagen - metabolism Collagen degradation Collagen stability Dentin - drug effects Dentin - metabolism Glycosaminoglycans - metabolism Humans Hydroxyproline - metabolism In Vitro Techniques Microscopy, Electron, Scanning Proteoglycans Proteoglycans - metabolism
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