Morphological Changes in Tissue When Using Polypropylene Implants with Adsorbed Multipotent Stromal Cells in Experiment
The subcutaneous tissue of rats after implantation of polypropylene materials with adsorbed bone marrow-derived mesenchymal multipotent stromal cells (MMSCs) was studied using light microscopy. Inflammation in response to implantation was mild, and the foreign material was encapsulated into a thin s...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2024-08, Vol.177 (4), p.534-543 |
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| creator | Maiborodin, I. V. Mikheeva, T. V. Sheplev, B. V. Yarin, G. Yu Onoprienko, N. V. Maiborodina, V. I. |
| description | The subcutaneous tissue of rats after implantation of polypropylene materials with adsorbed bone marrow-derived mesenchymal multipotent stromal cells (MMSCs) was studied using light microscopy. Inflammation in response to implantation was mild, and the foreign material was encapsulated into a thin strip of dense fibrous connective tissue with multinucleated macrophages. By 1 year after introduction of the monofilament and 6 and 12 months after implantation of the mesh product, some threads were deformed, broken, and had sharp edges. Small fragments of foreign material appeared in the adjacent tissues surrounded by their own relatively thick acellular capsule. As a result of preliminary adsorption of MMSCs on polypropylene, the thickness of the connective tissue capsule decreased, its vascularization increased, and the severity of inflammatory infiltration decreased. However, all effects of MMSCs adsorption in rats were transient and disappeared within 1 week. |
| doi_str_mv | 10.1007/s10517-024-06220-x |
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As a result of preliminary adsorption of MMSCs on polypropylene, the thickness of the connective tissue capsule decreased, its vascularization increased, and the severity of inflammatory infiltration decreased. 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However, all effects of MMSCs adsorption in rats were transient and disappeared within 1 week.</description><subject>Adsorption</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone implants</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Connective tissue</subject><subject>Connective tissues</subject><subject>Experiments</subject><subject>Fibroblasts</subject><subject>Internal Medicine</subject><subject>Laboratory animals</subject><subject>Laboratory Medicine</subject><subject>Light microscopy</subject><subject>Macrophages</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Morphology</subject><subject>Pathology</subject><subject>Pharmacy</subject><subject>Polypropylene</subject><subject>Stromal cells</subject><subject>Transplants & implants</subject><subject>Vascularization</subject><issn>0007-4888</issn><issn>1573-8221</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctKxDAUhoMoOl5ewIUE3Lip5tI26VIGb6AoqLgMvZzMVNKkJi3OvL0Zxwu4kCxCON_5zwkfQoeUnFJCxFmgJKMiISxNSM4YSRYbaEIzwRPJGN1EExKpJJVS7qDdEF5XT5LTbbTDC5bnBaMT9H7nfD93xs3aujR4Oi_tDAJuLX5qQxgBv8zB4ufQ2hl-cGbZe9cvDVjAN11vSjsE_N4Oc3zeBOcraPDdaIa2dwPYAT8O3nWrVDDmM_Ni0YNvu1jbR1u6NAEOvu499Hx58TS9Tm7vr26m57dJzbJ8SAqohNRcF6DrCkjKG6hrzpq0FDITWmesKbKCclJXORE5LXnKq0ZURHKd0VTzPXSyzo2Lv40QBtW1oY77lBbcGBSnJI2H5jKix3_QVzd6G7dbUUKSosh4pNiaqr0LwYNWffxR6ZeKErXSotZaVNSiPrWoRWw6-ooeqw6an5ZvDxHgayDEUjTgf2f_E_sB9iSaNw</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Maiborodin, I. 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V.</creatorcontrib><creatorcontrib>Mikheeva, T. V.</creatorcontrib><creatorcontrib>Sheplev, B. V.</creatorcontrib><creatorcontrib>Yarin, G. Yu</creatorcontrib><creatorcontrib>Onoprienko, N. V.</creatorcontrib><creatorcontrib>Maiborodina, V. I.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maiborodin, I. V.</au><au>Mikheeva, T. V.</au><au>Sheplev, B. V.</au><au>Yarin, G. Yu</au><au>Onoprienko, N. V.</au><au>Maiborodina, V. 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| subjects | Adsorption Biology Biomedical and Life Sciences Biomedicine Bone implants Bone marrow Cell Biology Connective tissue Connective tissues Experiments Fibroblasts Internal Medicine Laboratory animals Laboratory Medicine Light microscopy Macrophages Medical research Medicine Morphology Pathology Pharmacy Polypropylene Stromal cells Transplants & implants Vascularization |
| title | Morphological Changes in Tissue When Using Polypropylene Implants with Adsorbed Multipotent Stromal Cells in Experiment |
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