Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis
Background The global prevalence of obesity is increasing and represents a major public health challenge. However, there is a paucity of data regarding Helicobacter pylori ( H pylori ) eradication in people with obesity. The aim of the study is to examine the influence of obesity degree on H. pylori...
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| Veröffentlicht in: | Obesity surgery 2024-10, Vol.34 (10), p.3790-3795 |
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| creator | Laudanno, Oscar Ahumarán, Gabriel Thomé, Marcelo Gollo, Pablo Gonzalez, Patricia Khoury, Marina |
| description | Background
The global prevalence of obesity is increasing and represents a major public health challenge. However, there is a paucity of data regarding
Helicobacter pylori
(
H pylori
) eradication in people with obesity. The aim of the study is to examine the influence of obesity degree on
H. pylori
eradication in patients undergoing bariatric and metabolic surgery.
Methods
A post hoc analysis was conducted in a cohort of 204 adults patients (129 individuals diagnosed with obesity, 75 normal weight)
H. pylori
positive, included in two multicenter, prospective studies. Patients underwent a 14-day quadruple concomitant treatment, and
H. pylori
eradication was assessed using the 13C-urea breath test. The cohort was stratified according to body mass index (BMI), and statistical analyses were performed using chi-squared test, Kruskal–Wallis test, and logistic regression.
Results
Eradication rates were significantly lower in patients with obesity compared with normal weight individuals (68.2% vs. 88.0%, OR 0.29, 95% CI 0.13–0.63,
p
|
| doi_str_mv | 10.1007/s11695-024-07505-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3103450887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3103450887</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-ff8f7c87c8b1bdb3309d738890604089f1b312491006f5aca7f21879c9788f9f3</originalsourceid><addsrcrecordid>eNp9kc-KFDEQh4Mo7uzqC3iQgBcvrZWk_yTelkXdhQVB9Nwk6cpslp5Om6R36Afxfc3MrAoehEAK8tVXoX6EvGLwjgF07xNjrWoq4HUFXQNNtX9CNqwDWUHN5VOyAdVCJRUXZ-Q8pXsAzlrOn5MzoXhbNw3fkJ9fcdTZhynd-ZkazHvEiQaDyeeVJnzAeCj0NNBrHL0NRtuMkc7rGKKnGPXg7VFA_UTnUuGUE12mAeM2-GlLjY5e5-jtUbLDrE0oIpqWuMW4fqCXdA4p07twIPS4Jp9ekGdOjwlfPt4X5Punj9-urqvbL59vri5vK8ubNlfOSddZWY5hZjBCgBo6IaWCFmqQyjEjGK9V2VbrGm115ziTnbKqk9IpJy7I25N3juHHgin3O58sjqOeMCypFwxE3YCUXUHf_IPehyWW_x4oVrdlhBCF4ifKxpBSRNfP0e90XHsG_SG0_hRaX0Lrj6H1-9L0-lG9mB0Of1p-p1QAcQJSeZrK1v7O_o_2FzgqpUc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3114600633</pqid></control><display><type>article</type><title>Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Laudanno, Oscar ; Ahumarán, Gabriel ; Thomé, Marcelo ; Gollo, Pablo ; Gonzalez, Patricia ; Khoury, Marina</creator><creatorcontrib>Laudanno, Oscar ; Ahumarán, Gabriel ; Thomé, Marcelo ; Gollo, Pablo ; Gonzalez, Patricia ; Khoury, Marina</creatorcontrib><description>Background
The global prevalence of obesity is increasing and represents a major public health challenge. However, there is a paucity of data regarding
Helicobacter pylori
(
H pylori
) eradication in people with obesity. The aim of the study is to examine the influence of obesity degree on
H. pylori
eradication in patients undergoing bariatric and metabolic surgery.
Methods
A post hoc analysis was conducted in a cohort of 204 adults patients (129 individuals diagnosed with obesity, 75 normal weight)
H. pylori
positive, included in two multicenter, prospective studies. Patients underwent a 14-day quadruple concomitant treatment, and
H. pylori
eradication was assessed using the 13C-urea breath test. The cohort was stratified according to body mass index (BMI), and statistical analyses were performed using chi-squared test, Kruskal–Wallis test, and logistic regression.
Results
Eradication rates were significantly lower in patients with obesity compared with normal weight individuals (68.2% vs. 88.0%, OR 0.29, 95% CI 0.13–0.63,
p
< 0.01). Furthermore, within the population diagnosed with obesity, the degree of obesity correlated with decreased eradication rates, with class 3 (BMI 40.0–49.9) and class 4 (BMI ≥ 50.0) obesity showing the lowest rates (67% and 51%, with an OR 0.28 and 0.15 respectively,
p
< 0.01).
Conclusions
Our results indicate that obesity may influence
H. pylori
eradication, especially among severe obesity patients undergoing bariatric surgery, which could have implications for the development of ulcers and gastritis as well as the risk of gastric cancer. Tailored eradication strategies may be necessary to improve treatment efficacy in this population.</description><identifier>ISSN: 0960-8923</identifier><identifier>ISSN: 1708-0428</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-024-07505-w</identifier><identifier>PMID: 39264552</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Bariatric Surgery ; Body Mass Index ; Breath Tests ; Drug Therapy, Combination ; Female ; Gastrointestinal surgery ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; Prospective Studies ; Proton Pump Inhibitors - therapeutic use ; Surgery ; Treatment Outcome</subject><ispartof>Obesity surgery, 2024-10, Vol.34 (10), p.3790-3795</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-ff8f7c87c8b1bdb3309d738890604089f1b312491006f5aca7f21879c9788f9f3</cites><orcidid>0000-0002-5817-3292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-024-07505-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-024-07505-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39264552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laudanno, Oscar</creatorcontrib><creatorcontrib>Ahumarán, Gabriel</creatorcontrib><creatorcontrib>Thomé, Marcelo</creatorcontrib><creatorcontrib>Gollo, Pablo</creatorcontrib><creatorcontrib>Gonzalez, Patricia</creatorcontrib><creatorcontrib>Khoury, Marina</creatorcontrib><title>Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
The global prevalence of obesity is increasing and represents a major public health challenge. However, there is a paucity of data regarding
Helicobacter pylori
(
H pylori
) eradication in people with obesity. The aim of the study is to examine the influence of obesity degree on
H. pylori
eradication in patients undergoing bariatric and metabolic surgery.
Methods
A post hoc analysis was conducted in a cohort of 204 adults patients (129 individuals diagnosed with obesity, 75 normal weight)
H. pylori
positive, included in two multicenter, prospective studies. Patients underwent a 14-day quadruple concomitant treatment, and
H. pylori
eradication was assessed using the 13C-urea breath test. The cohort was stratified according to body mass index (BMI), and statistical analyses were performed using chi-squared test, Kruskal–Wallis test, and logistic regression.
Results
Eradication rates were significantly lower in patients with obesity compared with normal weight individuals (68.2% vs. 88.0%, OR 0.29, 95% CI 0.13–0.63,
p
< 0.01). Furthermore, within the population diagnosed with obesity, the degree of obesity correlated with decreased eradication rates, with class 3 (BMI 40.0–49.9) and class 4 (BMI ≥ 50.0) obesity showing the lowest rates (67% and 51%, with an OR 0.28 and 0.15 respectively,
p
< 0.01).
Conclusions
Our results indicate that obesity may influence
H. pylori
eradication, especially among severe obesity patients undergoing bariatric surgery, which could have implications for the development of ulcers and gastritis as well as the risk of gastric cancer. Tailored eradication strategies may be necessary to improve treatment efficacy in this population.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bariatric Surgery</subject><subject>Body Mass Index</subject><subject>Breath Tests</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>Prospective Studies</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>0960-8923</issn><issn>1708-0428</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQh4Mo7uzqC3iQgBcvrZWk_yTelkXdhQVB9Nwk6cpslp5Om6R36Afxfc3MrAoehEAK8tVXoX6EvGLwjgF07xNjrWoq4HUFXQNNtX9CNqwDWUHN5VOyAdVCJRUXZ-Q8pXsAzlrOn5MzoXhbNw3fkJ9fcdTZhynd-ZkazHvEiQaDyeeVJnzAeCj0NNBrHL0NRtuMkc7rGKKnGPXg7VFA_UTnUuGUE12mAeM2-GlLjY5e5-jtUbLDrE0oIpqWuMW4fqCXdA4p07twIPS4Jp9ekGdOjwlfPt4X5Punj9-urqvbL59vri5vK8ubNlfOSddZWY5hZjBCgBo6IaWCFmqQyjEjGK9V2VbrGm115ziTnbKqk9IpJy7I25N3juHHgin3O58sjqOeMCypFwxE3YCUXUHf_IPehyWW_x4oVrdlhBCF4ifKxpBSRNfP0e90XHsG_SG0_hRaX0Lrj6H1-9L0-lG9mB0Of1p-p1QAcQJSeZrK1v7O_o_2FzgqpUc</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Laudanno, Oscar</creator><creator>Ahumarán, Gabriel</creator><creator>Thomé, Marcelo</creator><creator>Gollo, Pablo</creator><creator>Gonzalez, Patricia</creator><creator>Khoury, Marina</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5817-3292</orcidid></search><sort><creationdate>20241001</creationdate><title>Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis</title><author>Laudanno, Oscar ; Ahumarán, Gabriel ; Thomé, Marcelo ; Gollo, Pablo ; Gonzalez, Patricia ; Khoury, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-ff8f7c87c8b1bdb3309d738890604089f1b312491006f5aca7f21879c9788f9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bariatric Surgery</topic><topic>Body Mass Index</topic><topic>Breath Tests</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>Prospective Studies</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laudanno, Oscar</creatorcontrib><creatorcontrib>Ahumarán, Gabriel</creatorcontrib><creatorcontrib>Thomé, Marcelo</creatorcontrib><creatorcontrib>Gollo, Pablo</creatorcontrib><creatorcontrib>Gonzalez, Patricia</creatorcontrib><creatorcontrib>Khoury, Marina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laudanno, Oscar</au><au>Ahumarán, Gabriel</au><au>Thomé, Marcelo</au><au>Gollo, Pablo</au><au>Gonzalez, Patricia</au><au>Khoury, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>34</volume><issue>10</issue><spage>3790</spage><epage>3795</epage><pages>3790-3795</pages><issn>0960-8923</issn><issn>1708-0428</issn><eissn>1708-0428</eissn><abstract>Background
The global prevalence of obesity is increasing and represents a major public health challenge. However, there is a paucity of data regarding
Helicobacter pylori
(
H pylori
) eradication in people with obesity. The aim of the study is to examine the influence of obesity degree on
H. pylori
eradication in patients undergoing bariatric and metabolic surgery.
Methods
A post hoc analysis was conducted in a cohort of 204 adults patients (129 individuals diagnosed with obesity, 75 normal weight)
H. pylori
positive, included in two multicenter, prospective studies. Patients underwent a 14-day quadruple concomitant treatment, and
H. pylori
eradication was assessed using the 13C-urea breath test. The cohort was stratified according to body mass index (BMI), and statistical analyses were performed using chi-squared test, Kruskal–Wallis test, and logistic regression.
Results
Eradication rates were significantly lower in patients with obesity compared with normal weight individuals (68.2% vs. 88.0%, OR 0.29, 95% CI 0.13–0.63,
p
< 0.01). Furthermore, within the population diagnosed with obesity, the degree of obesity correlated with decreased eradication rates, with class 3 (BMI 40.0–49.9) and class 4 (BMI ≥ 50.0) obesity showing the lowest rates (67% and 51%, with an OR 0.28 and 0.15 respectively,
p
< 0.01).
Conclusions
Our results indicate that obesity may influence
H. pylori
eradication, especially among severe obesity patients undergoing bariatric surgery, which could have implications for the development of ulcers and gastritis as well as the risk of gastric cancer. Tailored eradication strategies may be necessary to improve treatment efficacy in this population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39264552</pmid><doi>10.1007/s11695-024-07505-w</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5817-3292</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2024-10, Vol.34 (10), p.3790-3795 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Bariatric Surgery Body Mass Index Breath Tests Drug Therapy, Combination Female Gastrointestinal surgery Helicobacter Infections - drug therapy Helicobacter pylori Humans Male Medicine Medicine & Public Health Metabolism Middle Aged Obesity Obesity, Morbid - complications Obesity, Morbid - surgery Prospective Studies Proton Pump Inhibitors - therapeutic use Surgery Treatment Outcome |
| title | Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: A post hoc analysis |
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