Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs) are characterized by a high rate of thrombotic complications that contribute to morbidity and mortality. MPN-related thrombogenesis is assumed to be multifactorial, involving both procoagulant and proinflammatory processes. Whether impaired fibrinolysis also parti...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2024-11, Vol.22 (11), p.3199-3208
Hauptverfasser:	Bourrienne, Marie-Charlotte, Loyau, Stéphane, Faille, Dorothée, Gay, Juliette, Akhenak, Séléna, Farkh, Carine, Ollivier, Véronique, Solonomenjanahary, Mialitiana, Dupont, Sébastien, Choqueux, Christine, Villeval, Jean-Luc, Plo, Isabelle, Edmond, Valérie, Ho-Tin-Noé, Benoît, Ajzenberg, Nadine, Mazighi, Mikaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Blood Coagulation Calreticulin - genetics Case-Control Studies Female fibrin clot lysis time Fibrinolysin - metabolism Fibrinolysis Humans JAK2 protein Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Mutation myeloproliferative disorders Myeloproliferative Disorders - blood Myeloproliferative Disorders - genetics Phenotype Thrombosis - blood Thrombosis - genetics Tissue Plasminogen Activator - blood
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