The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge

Flavivirus infections result in a variety of outcomes, from clinically inapparent infections to severe, sometimes fatal cases characterized by hemorrhagic manifestations and vascular leakage leading to shock (dengue), meningomyeloencephalitis (West Nile), and congenital abnormalities (Zika). Althoug...

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Veröffentlicht in:	Antiviral research 2024-11, Vol.231, p.106002, Article 106002
Hauptverfasser:	Carneiro, Pedro H., Jimenez-Posada, E. Vanessa, Lopes, Eduarda, Mohana-Borges, Ronaldo, Biering, Scott B., Harris, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Apolipoprotein A-I - metabolism Apolipoprotein A-I - pharmacology Dengue - drug therapy Dengue - virology Dengue Virus - drug effects Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - virology Glycocalyx - metabolism Humans Mice Peptides - pharmacology Viral Nonstructural Proteins - metabolism West Nile virus - drug effects Zika Virus - drug effects
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