ISG15 is involved in chondrogenic differentiation through activation of IFN-γ signaling

Interferon-gamma (IFN-γ) was found to increase in the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). However, few studies have been conducted to elucidate the role of IFN-γ in cartilage metabolism and regeneration. In this study, we investigated whether cartilage...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-11, Vol.735, p.150629, Article 150629
Hauptverfasser:	Hwang, Hyun Sook, Kim, Ju-Ryoung, Lee, Mi Hyun, Park, Ji-Won, Kim, Hyun Ah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage regeneration Cell Differentiation Cell Line Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Cytokines - metabolism Gene Knockdown Techniques IFN-γ Interferon gamma Receptor Interferon-gamma - metabolism Interferon-gamma - pharmacology ISG15 ISGylation Mice Osteoarthritis Receptors, Interferon - genetics Receptors, Interferon - metabolism Regeneration Signal Transduction Ubiquitins - genetics Ubiquitins - metabolism
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