An anti-aging vaccine: BCG turns back the clock on remyelination failure

Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional respo...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2024-09, Vol.57 (9), p.2005-2007
Hauptverfasser: Kotah, Janssen M., Eggen, Bart J.L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination. Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.
ISSN:1074-7613
1097-4180
1097-4180
DOI:10.1016/j.immuni.2024.08.001