Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease
There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial 'AEROBIC' (NCT04299308) enrolled 60 older...
Gespeichert in:
| Veröffentlicht in: | The Journal of physiology 2024-09 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | The Journal of physiology |
| container_volume | |
| creator | Green, Zachary D John, Casey S Kueck, Paul J Blankenship, Anneka E Kemna, Riley E Johnson, Chelsea N Yoksh, Lauren E Best, Shaun R Donald, Joseph S Mahnken, Jonathan D Burns, Jeffrey M Vidoni, Eric D Morris, Jill K |
| description | There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial 'AEROBIC' (NCT04299308) enrolled 60 older adults who were cognitively healthy (n = 30) or cognitively impaired (n = 30) to characterize the acute brain responses to moderate [45-55% heart rate reserve (HRR)] and higher (65-75% HRR) intensity acute exercise. Each participant received two fluorodeoxyglucose positron emission tomography (FDG-PET) scans, one at rest and one following acute exercise. Change in cerebral glucose metabolism from rest to exercise was the primary outcome. Blood biomarker responses were also characterized as secondary outcomes. Whole grey matter FDG-PET standardized uptake value ratio (SUVR) differed between exercise (1.045 ± 0.082) and rest (0.985 ± 0.077) across subjects [Diff = -0.060, t(58) = 13.8, P |
| doi_str_mv | 10.1113/JP286923 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3102881777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3102881777</sourcerecordid><originalsourceid>FETCH-LOGICAL-c174t-14a2f50402c002e8e1feba7f37e4b6b96c4f14779b5545509e47410d9b534f323</originalsourceid><addsrcrecordid>eNpFkEtPwzAQhC0EoqUg8QuQb3AJeP2I42NVlZcqlQOcI9vZlKA8ip1IwK8niBZOqx19O9oZQs6BXQOAuHl84llquDggU5CpSbQ24pBMGeM8EVrBhJzE-MYYCGbMMZkIw1VmUpiS9dwPPVL8wOCriNTWPYZIXbBVSzf14LtRbLC3rqur2NBRtZuq3VDbFnRef71i1WC4jLQYr23EU3JU2jri2W7OyMvt8nlxn6zWdw-L-SrxoGWfgLS8VEwy7scnMUMo0VldCo3Spc6kXpYgxxhOKakUMyi1BFaMu5Cl4GJGrn59t6F7HzD2eVNFj3VtW-yGmAtgPMtAa_2P-tDFGLDMt6FqbPjMgeU_9eX7-kb0Yuc6uAaLP3Dfl_gGv-RozA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3102881777</pqid></control><display><type>article</type><title>Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Green, Zachary D ; John, Casey S ; Kueck, Paul J ; Blankenship, Anneka E ; Kemna, Riley E ; Johnson, Chelsea N ; Yoksh, Lauren E ; Best, Shaun R ; Donald, Joseph S ; Mahnken, Jonathan D ; Burns, Jeffrey M ; Vidoni, Eric D ; Morris, Jill K</creator><creatorcontrib>Green, Zachary D ; John, Casey S ; Kueck, Paul J ; Blankenship, Anneka E ; Kemna, Riley E ; Johnson, Chelsea N ; Yoksh, Lauren E ; Best, Shaun R ; Donald, Joseph S ; Mahnken, Jonathan D ; Burns, Jeffrey M ; Vidoni, Eric D ; Morris, Jill K</creatorcontrib><description>There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial 'AEROBIC' (NCT04299308) enrolled 60 older adults who were cognitively healthy (n = 30) or cognitively impaired (n = 30) to characterize the acute brain responses to moderate [45-55% heart rate reserve (HRR)] and higher (65-75% HRR) intensity acute exercise. Each participant received two fluorodeoxyglucose positron emission tomography (FDG-PET) scans, one at rest and one following acute exercise. Change in cerebral glucose metabolism from rest to exercise was the primary outcome. Blood biomarker responses were also characterized as secondary outcomes. Whole grey matter FDG-PET standardized uptake value ratio (SUVR) differed between exercise (1.045 ± 0.082) and rest (0.985 ± 0.077) across subjects [Diff = -0.060, t(58) = 13.8, P < 0.001] regardless of diagnosis. Exercise increased lactate area under the curve (AUC) [F(1,56) = 161.99, P < 0.001] more in the higher intensity group [mean difference (MD) = 97.0 ± 50.8] than the moderate intensity group (MD = 40.3 ± 27.5; t = -5.252, P < 0.001). Change in lactate AUC and FDG-PET SUVR correlated significantly (R
= 0.179, P < 0.001). Acute exercise decreased whole grey matter cerebral glucose metabolism. This effect tracked with the systemic lactate response, suggesting that lactate may serve as a key brain fuel during exercise. Direct measurements of brain lactate metabolism in response to exercise are warranted. KEY POINTS: Acute exercise is associated with a drop in global brain glucose metabolism in both cognitively healthy older adults and those with Alzheimer's disease. Blood lactate levels increase following acute exercise. Change in brain metabolism tracks with blood lactate, suggesting it may be an important brain fuel. Acute exercise stimulates changes in brain-derived neurotrophic factor and other blood biomarkers.</description><identifier>ISSN: 0022-3751</identifier><identifier>ISSN: 1469-7793</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/JP286923</identifier><identifier>PMID: 39258961</identifier><language>eng</language><publisher>England</publisher><ispartof>The Journal of physiology, 2024-09</ispartof><rights>2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c174t-14a2f50402c002e8e1feba7f37e4b6b96c4f14779b5545509e47410d9b534f323</cites><orcidid>0000-0002-9102-2058 ; 0000-0001-5181-7131 ; 0000-0001-5911-4190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39258961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Green, Zachary D</creatorcontrib><creatorcontrib>John, Casey S</creatorcontrib><creatorcontrib>Kueck, Paul J</creatorcontrib><creatorcontrib>Blankenship, Anneka E</creatorcontrib><creatorcontrib>Kemna, Riley E</creatorcontrib><creatorcontrib>Johnson, Chelsea N</creatorcontrib><creatorcontrib>Yoksh, Lauren E</creatorcontrib><creatorcontrib>Best, Shaun R</creatorcontrib><creatorcontrib>Donald, Joseph S</creatorcontrib><creatorcontrib>Mahnken, Jonathan D</creatorcontrib><creatorcontrib>Burns, Jeffrey M</creatorcontrib><creatorcontrib>Vidoni, Eric D</creatorcontrib><creatorcontrib>Morris, Jill K</creatorcontrib><title>Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial 'AEROBIC' (NCT04299308) enrolled 60 older adults who were cognitively healthy (n = 30) or cognitively impaired (n = 30) to characterize the acute brain responses to moderate [45-55% heart rate reserve (HRR)] and higher (65-75% HRR) intensity acute exercise. Each participant received two fluorodeoxyglucose positron emission tomography (FDG-PET) scans, one at rest and one following acute exercise. Change in cerebral glucose metabolism from rest to exercise was the primary outcome. Blood biomarker responses were also characterized as secondary outcomes. Whole grey matter FDG-PET standardized uptake value ratio (SUVR) differed between exercise (1.045 ± 0.082) and rest (0.985 ± 0.077) across subjects [Diff = -0.060, t(58) = 13.8, P < 0.001] regardless of diagnosis. Exercise increased lactate area under the curve (AUC) [F(1,56) = 161.99, P < 0.001] more in the higher intensity group [mean difference (MD) = 97.0 ± 50.8] than the moderate intensity group (MD = 40.3 ± 27.5; t = -5.252, P < 0.001). Change in lactate AUC and FDG-PET SUVR correlated significantly (R
= 0.179, P < 0.001). Acute exercise decreased whole grey matter cerebral glucose metabolism. This effect tracked with the systemic lactate response, suggesting that lactate may serve as a key brain fuel during exercise. Direct measurements of brain lactate metabolism in response to exercise are warranted. KEY POINTS: Acute exercise is associated with a drop in global brain glucose metabolism in both cognitively healthy older adults and those with Alzheimer's disease. Blood lactate levels increase following acute exercise. Change in brain metabolism tracks with blood lactate, suggesting it may be an important brain fuel. Acute exercise stimulates changes in brain-derived neurotrophic factor and other blood biomarkers.</description><issn>0022-3751</issn><issn>1469-7793</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkEtPwzAQhC0EoqUg8QuQb3AJeP2I42NVlZcqlQOcI9vZlKA8ip1IwK8niBZOqx19O9oZQs6BXQOAuHl84llquDggU5CpSbQ24pBMGeM8EVrBhJzE-MYYCGbMMZkIw1VmUpiS9dwPPVL8wOCriNTWPYZIXbBVSzf14LtRbLC3rqur2NBRtZuq3VDbFnRef71i1WC4jLQYr23EU3JU2jri2W7OyMvt8nlxn6zWdw-L-SrxoGWfgLS8VEwy7scnMUMo0VldCo3Spc6kXpYgxxhOKakUMyi1BFaMu5Cl4GJGrn59t6F7HzD2eVNFj3VtW-yGmAtgPMtAa_2P-tDFGLDMt6FqbPjMgeU_9eX7-kb0Yuc6uAaLP3Dfl_gGv-RozA</recordid><startdate>20240911</startdate><enddate>20240911</enddate><creator>Green, Zachary D</creator><creator>John, Casey S</creator><creator>Kueck, Paul J</creator><creator>Blankenship, Anneka E</creator><creator>Kemna, Riley E</creator><creator>Johnson, Chelsea N</creator><creator>Yoksh, Lauren E</creator><creator>Best, Shaun R</creator><creator>Donald, Joseph S</creator><creator>Mahnken, Jonathan D</creator><creator>Burns, Jeffrey M</creator><creator>Vidoni, Eric D</creator><creator>Morris, Jill K</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9102-2058</orcidid><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid><orcidid>https://orcid.org/0000-0001-5911-4190</orcidid></search><sort><creationdate>20240911</creationdate><title>Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease</title><author>Green, Zachary D ; John, Casey S ; Kueck, Paul J ; Blankenship, Anneka E ; Kemna, Riley E ; Johnson, Chelsea N ; Yoksh, Lauren E ; Best, Shaun R ; Donald, Joseph S ; Mahnken, Jonathan D ; Burns, Jeffrey M ; Vidoni, Eric D ; Morris, Jill K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c174t-14a2f50402c002e8e1feba7f37e4b6b96c4f14779b5545509e47410d9b534f323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Green, Zachary D</creatorcontrib><creatorcontrib>John, Casey S</creatorcontrib><creatorcontrib>Kueck, Paul J</creatorcontrib><creatorcontrib>Blankenship, Anneka E</creatorcontrib><creatorcontrib>Kemna, Riley E</creatorcontrib><creatorcontrib>Johnson, Chelsea N</creatorcontrib><creatorcontrib>Yoksh, Lauren E</creatorcontrib><creatorcontrib>Best, Shaun R</creatorcontrib><creatorcontrib>Donald, Joseph S</creatorcontrib><creatorcontrib>Mahnken, Jonathan D</creatorcontrib><creatorcontrib>Burns, Jeffrey M</creatorcontrib><creatorcontrib>Vidoni, Eric D</creatorcontrib><creatorcontrib>Morris, Jill K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Green, Zachary D</au><au>John, Casey S</au><au>Kueck, Paul J</au><au>Blankenship, Anneka E</au><au>Kemna, Riley E</au><au>Johnson, Chelsea N</au><au>Yoksh, Lauren E</au><au>Best, Shaun R</au><au>Donald, Joseph S</au><au>Mahnken, Jonathan D</au><au>Burns, Jeffrey M</au><au>Vidoni, Eric D</au><au>Morris, Jill K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>2024-09-11</date><risdate>2024</risdate><issn>0022-3751</issn><issn>1469-7793</issn><eissn>1469-7793</eissn><abstract>There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial 'AEROBIC' (NCT04299308) enrolled 60 older adults who were cognitively healthy (n = 30) or cognitively impaired (n = 30) to characterize the acute brain responses to moderate [45-55% heart rate reserve (HRR)] and higher (65-75% HRR) intensity acute exercise. Each participant received two fluorodeoxyglucose positron emission tomography (FDG-PET) scans, one at rest and one following acute exercise. Change in cerebral glucose metabolism from rest to exercise was the primary outcome. Blood biomarker responses were also characterized as secondary outcomes. Whole grey matter FDG-PET standardized uptake value ratio (SUVR) differed between exercise (1.045 ± 0.082) and rest (0.985 ± 0.077) across subjects [Diff = -0.060, t(58) = 13.8, P < 0.001] regardless of diagnosis. Exercise increased lactate area under the curve (AUC) [F(1,56) = 161.99, P < 0.001] more in the higher intensity group [mean difference (MD) = 97.0 ± 50.8] than the moderate intensity group (MD = 40.3 ± 27.5; t = -5.252, P < 0.001). Change in lactate AUC and FDG-PET SUVR correlated significantly (R
= 0.179, P < 0.001). Acute exercise decreased whole grey matter cerebral glucose metabolism. This effect tracked with the systemic lactate response, suggesting that lactate may serve as a key brain fuel during exercise. Direct measurements of brain lactate metabolism in response to exercise are warranted. KEY POINTS: Acute exercise is associated with a drop in global brain glucose metabolism in both cognitively healthy older adults and those with Alzheimer's disease. Blood lactate levels increase following acute exercise. Change in brain metabolism tracks with blood lactate, suggesting it may be an important brain fuel. Acute exercise stimulates changes in brain-derived neurotrophic factor and other blood biomarkers.</abstract><cop>England</cop><pmid>39258961</pmid><doi>10.1113/JP286923</doi><orcidid>https://orcid.org/0000-0002-9102-2058</orcidid><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid><orcidid>https://orcid.org/0000-0001-5911-4190</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 2024-09 |
| issn | 0022-3751 1469-7793 1469-7793 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3102881777 |
| source | Wiley Online Library Journals Frontfile Complete |
| title | Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T03%3A10%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20exercise%20alters%20brain%20glucose%20metabolism%20in%20aging%20and%20Alzheimer's%20disease&rft.jtitle=The%20Journal%20of%20physiology&rft.au=Green,%20Zachary%20D&rft.date=2024-09-11&rft.issn=0022-3751&rft.eissn=1469-7793&rft_id=info:doi/10.1113/JP286923&rft_dat=%3Cproquest_cross%3E3102881777%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3102881777&rft_id=info:pmid/39258961&rfr_iscdi=true |