Copper Complexes with Protein‐Based N‐Donor Ligands as cis‐Selective Nascent Cyclopropanases

In this study, we aimed to develop protein‐based metal ligands to catalyze cis‐selective cyclopropanation using the TM1459 cupin protein superfamily. Copper complexes with TM1459 mutants containing the 3‐His metal‐binding site exhibited excellent diastereoselectivity in cyclopropanation reactions wi...

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Veröffentlicht in:	Chemistry : a European journal 2024-12, Vol.30 (70), p.e202402803-n/a
Hauptverfasser:	Fujieda, Nobutaka, Matsuo, Atsuki, Itoh, Shinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial metalloenzymes Binding Sites Catalysis Coordination Complexes - chemistry Copper Copper - chemistry Copper compounds Cupin Cyclopropanation Cyclopropanes - chemistry Enantiomers Ligands Metallocarbene Mononuclear copper enzyme Proteins Stereoisomerism Stereoselectivity Styrene Styrene - chemistry
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