Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function

Chaperone-mediated autophagy (CMA) is a selective form of autophagy that contributes to the maintenance of cellular homeostasis. CMA activity declines with age in most tissues and systems, including the immune system, due to a reduction in levels of lysosome-associated membrane protein type 2A (LAMP...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-09, Vol.121 (38), p.e2322929121
Hauptverfasser:	Reynolds, Cara A, Pelka, Sandra, Gjergjova, Floralba, Tasset, Inmaculada, Khawaja, Rabia R, Lindenau, Kristen, Krause, Gregory J, Gavathiotis, Evripidis, Cuervo, Ana Maria, Macian, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - immunology Aging - metabolism Animals Autophagy Chaperone-Mediated Autophagy Down-regulation Homeostasis Immune response Immune system Immunosuppressive agents Lymphocyte Activation Lymphocytes Lymphocytes T Lysosomal-Associated Membrane Protein 2 - genetics Lysosomal-Associated Membrane Protein 2 - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Population genetics Populations Proteomes Proteomics Receptor mechanisms T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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