Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice

Abstract Reproductive function in mammals depends on the ability of progesterone (P4) to suppress pulsatile gonadotrophin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in a homeostatic-negative feedback loop. Previous research identified that cells upstream from GnRH neurons expres...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2024-08, Vol.165 (10)
Hauptverfasser:	Dillon, Kendra M, Lohr, Dayanara B, Novak, Alyssa G, Petriv, Anna-Maria V, Neifert, Nicole T, Moore, Aleisha M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arcuate nucleus Arcuate Nucleus of Hypothalamus - metabolism Clonal deletion Control theory Dynorphin Dynorphins - genetics Dynorphins - metabolism Feedback Feedback loops Feedback, Physiological Female Females Gene expression Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Kiss1 protein Kisspeptins - genetics Kisspeptins - metabolism Luteinizing hormone Luteinizing Hormone - metabolism Mice Mice, Knockout Negative feedback Neurokinin Neurokinin B Neurokinin B - genetics Neurokinin B - metabolism Neurons Neurons - metabolism Pituitary (anterior) Progesterone Progesterone - metabolism Progesterone receptors Pulse generators Receptor mechanisms Receptors Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Secretion
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