Nesfatin-1 is a regulator of inflammation with implications during obesity and metabolic syndrome
Nesfatin-1, derived from the nucleobindin 2 (NUCB2) precursor, is a potent anorexigenic peptide that was discovered in 2006. Since its identification in the hypothalamus, it has been shown to have wide ranging actions within and outside of the central nervous system. One of these actions is the regu...
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| Veröffentlicht in: | Appetite 2024-12, Vol.203, p.107669, Article 107669 |
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| creator | Steffen, Tara L. Stafford, Joshua D. Samson, Willis K. Yosten, Gina L.C. |
| description | Nesfatin-1, derived from the nucleobindin 2 (NUCB2) precursor, is a potent anorexigenic peptide that was discovered in 2006. Since its identification in the hypothalamus, it has been shown to have wide ranging actions within and outside of the central nervous system. One of these actions is the regulation of inflammation, which could potentially be exploited therapeutically in the context of obesity-associated inflammation in adipose tissue. Here, we review recent advances in our knowledge about the ability of nesfatin-1 to control inflammation by regulating NFκB signaling, which likely attenuates pro-inflammatory cytokine production and inhibits apoptosis.
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| doi_str_mv | 10.1016/j.appet.2024.107669 |
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| identifier | ISSN: 0195-6663 |
| ispartof | Appetite, 2024-12, Vol.203, p.107669, Article 107669 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue - metabolism Animals Apoptosis Calcium-Binding Proteins - metabolism Cytokines - metabolism DNA-Binding Proteins - metabolism Humans Hypothalamus - metabolism Inflammation Metabolic Syndrome - metabolism Nerve Tissue Proteins - metabolism Nesfatin-1 NF-kappa B - metabolism NUCB2 Nucleobindins - metabolism Obesity Obesity - metabolism Peptide Signal Transduction |
| title | Nesfatin-1 is a regulator of inflammation with implications during obesity and metabolic syndrome |
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