The cAMP/PKA signaling pathway conditions cardiac performance in experimental animals with metabolic syndrome

Metabolic syndrome (MetS) increases the risk of coronary artery disease, but effects of this condition on the working myocardium remain to be fully elucidated. In the present study we evaluated the consequences of diet-induced metabolic disorders on cardiac function and myocyte performance using fem...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2024-11, Vol.196, p.35-51
Hauptverfasser:	Pizzo, Emanuele, Cervantes, Daniel O., Ripa, Valentina, Filardo, Andrea, Berrettoni, Silvia, Ketkar, Harshada, Jagana, Vineeta, Di Stefano, Valeria, Singh, Kanwardeep, Ezzati, Asha, Ghadirian, Kash, Kouril, Anna, Jacobson, Jason T., Bisserier, Malik, Jain, Sudhir, Rota, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell mechanics Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Diet, Western - adverse effects Disease Models, Animal Female Heart - physiopathology Heart Rate Metabolic syndrome Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Metabolic Syndrome - physiopathology Mice Mice, Inbred C57BL Myocardial Contraction Myocardium - metabolism Myocardium - pathology Myocytes Myocytes, Cardiac - metabolism Obesity Receptors, Adrenergic, beta - metabolism Signal Transduction
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