PRMT1 promotes radiotherapy resistance in glioma stem cells by inhibiting ferroptosis

Purpose The existence of glioma stem cells (GSCs) in cancer is related to glioma radiotherapy resistance. In this research, the effect of protein arginine methyltransferase 1 (PRMT1) on the radiosensitivity of glioma stem cell (GSC)-like cells, as well as its underlying mechanism, was investigated....

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Veröffentlicht in:	Japanese journal of radiology 2025-01, Vol.43 (1), p.129-137
Hauptverfasser:	Li, Hong, Qi, Xiaoyan, He, Lijun, Yang, Hao, Ju, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Brain Neoplasms - genetics Brain Neoplasms - radiotherapy Cell Line, Tumor Cell self-renewal Cell survival Ferroptosis Ferroptosis - genetics Flow Cytometry Gene expression Glioblastoma Glioma Glioma - genetics Glioma - radiotherapy Glioma cells Glutathione Humans Imaging Medicine Medicine & Public Health Neoplastic Stem Cells - radiation effects Nestin Nuclear Medicine Original Article Phenotypes Protein arginine methyltransferase Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Proteins Radiation therapy Radiation tolerance Radiation Tolerance - genetics Radiology Radiosensitivity Radiotherapy Reactive oxygen species Repressor Proteins - genetics Repressor Proteins - metabolism Stem cells Survival Transfection
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