Immune checkpoint inhibitors in infectious disease

Summary Following success in cancer immunotherapy, immune checkpoint blockade is emerging as an exciting potential treatment for some infectious diseases, specifically two chronic viral infections, HIV and hepatitis B. Here, we will discuss the function of immune checkpoints, their role in infectiou...

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Veröffentlicht in:	Immunological reviews 2024-11, Vol.328 (1), p.350-371
Hauptverfasser:	King, Hannah A. D., Lewin, Sharon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antibodies in Therapeutics Antiretroviral therapy Apoptosis Biocompatibility Cancer Cancer immunotherapy Cancer vaccines Cell death Hepatitis B HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - immunology Human immunodeficiency virus Humans immune checkpoint Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune response Immune system Immunotherapy Immunotherapy - methods In vivo methods and tests Infectious diseases Invited Review Latency Lymphocytes Lymphocytes T PD‐1 Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Recovery of function T-Lymphocytes - immunology Viral infections Virus Latency - drug effects Virus Latency - immunology
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