A User‐Driven Framework for Dose Selection in Pregnancy: Proof of Concept for Sertraline

Despite growing knowledge of pregnancy‐induced changes in physiology that may alter maternal and fetal pharmacokinetics, evidence‐based antenatal doses are lacking for most drugs. Pharmacokinetic modeling and expanding clinical data in pregnancy may support antenatal doses. We aimed to develop and p...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2025-01, Vol.117 (1), p.214-224
Hauptverfasser:	Koldeweij, Charlotte, Dibbets, Caroline, Franklin, Bryony D., Scheepers, Hubertina C. J., Wildt, Saskia N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents - administration & dosage Antidepressive Agents - adverse effects Antidepressive Agents - pharmacokinetics Anxiety Disorders - drug therapy Dose-Response Relationship, Drug Female Humans Pilot Projects Pregnancy Pregnancy Complications - drug therapy Proof of Concept Study Risk Assessment Selective Serotonin Reuptake Inhibitors - administration & dosage Selective Serotonin Reuptake Inhibitors - adverse effects Selective Serotonin Reuptake Inhibitors - pharmacokinetics Sertraline - administration & dosage Sertraline - adverse effects Sertraline - pharmacokinetics
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