Serotonin transporter deficiency in mice results in an increased susceptibility to HTR2B-dependent pro-fibrotic mechanisms in the cardiac valves and left ventricular myocardium

•Remodeling in SERT-/- mice occurs earlier in the mitral valve than in other cardiac substructures.•Left side heart valve interstitial cells are more sensitive than right side to 5HT stimulation.•TGFβ1 upregulated HTR2B expression in valve interstitial cells from all valves, and fibroblasts. Increas...

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Veröffentlicht in:	Cardiovascular pathology 2025-01, Vol.74, p.107689, Article 107689
Hauptverfasser:	Castillero, Estibaliz, Camillo, Chiara, Levine, Dov, D'Angelo, Alex M., Kosuri, Yaagnik, Grau, Juan B., Levy, Robert J., Ferrari, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	5HT Animals Cardiac fibrosis Cells, Cultured Collagen Type I - genetics Collagen Type I - metabolism Collagen Type I, alpha 1 Chain - genetics Collagen Type I, alpha 1 Chain - metabolism Disease Models, Animal Female Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Heart Valves - metabolism Heart Valves - pathology Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mitral valve Mitral Valve Insufficiency - metabolism Mitral Valve Insufficiency - pathology Mitral Valve Insufficiency - physiopathology Myocardium - metabolism Myocardium - pathology Phenotype Receptor, Serotonin, 5-HT2B - genetics Receptor, Serotonin, 5-HT2B - metabolism Serotonin Plasma Membrane Transport Proteins - deficiency Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Signal Transduction Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Valvulopathy Ventricular Function, Left Ventricular Remodeling
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