Huang-Lian-Jie-Du Decoction alleviates diabetic encephalopathy by regulating inflammation and pyroptosis via suppression of AGEs/RAGE/NF-κB pathways

Cognitive dysfunction associated with diabetes, known as diabetic encephalopathy (DE), is a grave neurodegenerative condition triggered by diabetes, and persistent inflammation plays a vital role in its development. The renowned traditional Chinese medicine Huang-Lian-Jie-Du Decoction (HLJDD) is cli...

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Veröffentlicht in:	Journal of ethnopharmacology 2025-01, Vol.337 (Pt 1), p.118787, Article 118787
Hauptverfasser:	Zhuang, Guo-Dong, Deng, Si-Min, Chen, Meng-Di, Deng, Chao-Fan, Gu, Wen-Ting, Wang, Shu-Mei, Tang, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	AGEs Animals Cognitive Dysfunction - drug therapy Diabetes Mellitus, Experimental - drug therapy Diabetic encephalopathy Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Glycation End Products, Advanced - metabolism Huang-Lian-Jie-Du Decoction Inflammation Inflammation - drug therapy Male Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB Pyroptosis Pyroptosis - drug effects RAGE Receptor for Advanced Glycation End Products - metabolism Signal Transduction - drug effects Streptozocin
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