Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia among the elderly, accounting for 60 %–70 % of cases. At present, the pathogenesis of this condition remains unclear, but the hydrolysis of acetylcholine (ACh) is thought to play a role. Acetylcholinesterase (AChE) can break down ACh...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-12, Vol.279, p.116810, Article 116810
Hauptverfasser:	Zhao, Xingyi, Hu, Qiaoguan, Wang, Xiaoqian, Li, Chunting, Chen, Xiao, Zhao, Dong, Qiu, Yue, Xu, Haoyu, Wang, Jiaqi, Ren, Le, Zhang, Na, Li, Shuang, Gong, Ping, Hou, Yunlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism AChE Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Animals Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Donepezil Dual inhibitors Humans Molecular Structure Structure-Activity Relationship Tacrine
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