Ferroptosis in the neurovascular unit after spinal cord injury
The mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis an...
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| Veröffentlicht in: | Experimental neurology 2024-11, Vol.381, p.114943, Article 114943 |
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| container_title | Experimental neurology |
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| creator | Huang, Yushan Bai, Jinzhu |
| description | The mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis and attenuate secondary spinal cord injury(SCI). This review focuses on the mechanisms of ferroptosis in NVU cells and NVU-targeted therapeutic strategies according to the stages of SCI, and analyzes possible future research directions. |
| doi_str_mv | 10.1016/j.expneurol.2024.114943 |
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The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis and attenuate secondary spinal cord injury(SCI). 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| ispartof | Experimental neurology, 2024-11, Vol.381, p.114943, Article 114943 |
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| subjects | Ferroptosis Neurovascular unit Secondary injury Spinal cord injury |
| title | Ferroptosis in the neurovascular unit after spinal cord injury |
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