Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

Prior studies have described the complex interplay that exists between glioma cells and neurons; however, the electrophysiological properties endogenous to glioma cells remain obscure. To address this, we employed Patch-sequencing (Patch-seq) on human glioma specimens and found that one-third of pat...

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Veröffentlicht in:	Cancer cell 2024-10, Vol.42 (10), p.1713-1728.e6
Hauptverfasser:	Curry, Rachel N., Ma, Qianqian, McDonald, Malcolm F., Ko, Yeunjung, Srivastava, Snigdha, Chin, Pey-Shyuan, He, Peihao, Lozzi, Brittney, Athukuri, Prazwal, Jing, Junzhan, Wang, Su, Harmanci, Arif O., Arenkiel, Benjamin, Jiang, Xiaolong, Deneen, Benjamin, Rao, Ganesh, Serin Harmanci, Akdes
Format:	Artikel
Sprache:	eng
Schlagworte:	action potentials GABAergic neurons glioma machine learning oligodendrocyte precursor cells Patch-seq scRNA-seq
Online-Zugang:	Volltext
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