Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients

Aim: To understand how vitamin D receptor gene polymorphism (VDR rs2228570) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province. Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hyper...

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Veröffentlicht in:	Wiadomości lekarskie (1960) 2024, Vol.77 (7), p.1387-1393
Hauptverfasser:	Jabir, Aseel R, Saheb, Hussein A, Mohammad, Bassim I, Sultan, Ahmed M, Kadhim, Sinaa Abdul Amir, Swadi, Asma A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Blood Pressure - genetics Cross-Sectional Studies Essential Hypertension - genetics Female Genetic Predisposition to Disease Genotype Humans Hypertension - genetics Iraq Male Middle Aged Polymorphism, Genetic Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics
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container_title	Wiadomości lekarskie (1960)
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creator	Jabir, Aseel R Saheb, Hussein A Mohammad, Bassim I Sultan, Ahmed M Kadhim, Sinaa Abdul Amir Swadi, Asma A
description	Aim: To understand how vitamin D receptor gene polymorphism (VDR rs2228570) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province. Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene. Results: The most frequent allele was A (121, 67%) while the most frequent genotype was AG (55, 61%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs 2228570 on blood pressure indicates (the mean systolic blood pressure in AA, AG, and GG carrier patients was 149, 150 and 166 respectively, P=0.29. On the other hand, the mean diastolic blood pressure in AA, AG, and GG carrier patients was 89, 89, and 94 respectively P=0.6) there was no statistically significant effect on systolic and diastolic blood pressure. Conclusions: there is no statistically significant effect of VDR rs2228570 on SBP and DBP (p = 0.6), vitamin D receptor gene polymorphism rs2228570 was related to vitamin D level.
doi_str_mv	10.36740/WLek202407112
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Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene. Results: The most frequent allele was A (121, 67%) while the most frequent genotype was AG (55, 61%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs 2228570 on blood pressure indicates (the mean systolic blood pressure in AA, AG, and GG carrier patients was 149, 150 and 166 respectively, P=0.29. On the other hand, the mean diastolic blood pressure in AA, AG, and GG carrier patients was 89, 89, and 94 respectively P=0.6) there was no statistically significant effect on systolic and diastolic blood pressure. 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Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene. Results: The most frequent allele was A (121, 67%) while the most frequent genotype was AG (55, 61%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs 2228570 on blood pressure indicates (the mean systolic blood pressure in AA, AG, and GG carrier patients was 149, 150 and 166 respectively, P=0.29. On the other hand, the mean diastolic blood pressure in AA, AG, and GG carrier patients was 89, 89, and 94 respectively P=0.6) there was no statistically significant effect on systolic and diastolic blood pressure. Conclusions: there is no statistically significant effect of VDR rs2228570 on SBP and DBP (p = 0.6), vitamin D receptor gene polymorphism rs2228570 was related to vitamin D level.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Essential Hypertension - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Iraq</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Calcitriol - genetics</subject><issn>0043-5147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PAkEQQLfQCEFaS7MlFuDs921pUJRIQqHR8rLczcnqfbF7xPDvvSiaOM00b14yj5ALBjOhjYTr1xV-cOASDGP8hAwBpJgqJs2AjGN8h360YqDtGRkIyyVjwgxJ_eI7V_ma3tKAGbZdE-gb1khD5JwnygCdLNaPyyvaNuWhakK79bGiLsYm867DnH76bksxRqw770q6PbQYOqyjb2rae5fB7TxtXed7IJ6T08KVEcfHPSJPi7vn-cN0tb5fzm9W08wqM1WbPNGaMyO1AS2BoxYZJMAKm4HKLWSW8f4bmdhE5jpH65gSBbDcQb4BMSKTH2sbmt0eY5dWPmZYlq7GZh9TwYApJaQ1PTr7QbPQxBiwSNvgKxcOKYP0O2z6L2x_cHl07zcV5n_4b1LxBcHRc-M</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Jabir, Aseel R</creator><creator>Saheb, Hussein A</creator><creator>Mohammad, Bassim I</creator><creator>Sultan, Ahmed M</creator><creator>Kadhim, Sinaa Abdul Amir</creator><creator>Swadi, Asma A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients</title><author>Jabir, Aseel R ; Saheb, Hussein A ; Mohammad, Bassim I ; Sultan, Ahmed M ; Kadhim, Sinaa Abdul Amir ; Swadi, Asma A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c957-5bd86621746706402e63c0801f9c05d90c91206548984d6de9a153f01da0db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Essential Hypertension - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Iraq</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Calcitriol - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jabir, Aseel R</creatorcontrib><creatorcontrib>Saheb, Hussein A</creatorcontrib><creatorcontrib>Mohammad, Bassim I</creatorcontrib><creatorcontrib>Sultan, Ahmed M</creatorcontrib><creatorcontrib>Kadhim, Sinaa Abdul Amir</creatorcontrib><creatorcontrib>Swadi, Asma A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiadomości lekarskie (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jabir, Aseel R</au><au>Saheb, Hussein A</au><au>Mohammad, Bassim I</au><au>Sultan, Ahmed M</au><au>Kadhim, Sinaa Abdul Amir</au><au>Swadi, Asma A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients</atitle><jtitle>Wiadomości lekarskie (1960)</jtitle><addtitle>Wiad Lek</addtitle><date>2024</date><risdate>2024</risdate><volume>77</volume><issue>7</issue><spage>1387</spage><epage>1393</epage><pages>1387-1393</pages><issn>0043-5147</issn><abstract>Aim: To understand how vitamin D receptor gene polymorphism (VDR rs2228570) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province. Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene. Results: The most frequent allele was A (121, 67%) while the most frequent genotype was AG (55, 61%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs 2228570 on blood pressure indicates (the mean systolic blood pressure in AA, AG, and GG carrier patients was 149, 150 and 166 respectively, P=0.29. On the other hand, the mean diastolic blood pressure in AA, AG, and GG carrier patients was 89, 89, and 94 respectively P=0.6) there was no statistically significant effect on systolic and diastolic blood pressure. Conclusions: there is no statistically significant effect of VDR rs2228570 on SBP and DBP (p = 0.6), vitamin D receptor gene polymorphism rs2228570 was related to vitamin D level.</abstract><cop>Poland</cop><pmid>39241137</pmid><doi>10.36740/WLek202407112</doi><tpages>7</tpages></addata></record>
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subjects	Adult Aged Blood Pressure - genetics Cross-Sectional Studies Essential Hypertension - genetics Female Genetic Predisposition to Disease Genotype Humans Hypertension - genetics Iraq Male Middle Aged Polymorphism, Genetic Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics
title	Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients
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