Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers
Background Axillary staging in early-stage breast cancer can impact adjuvant treatment options but also has associated morbidity. The incidence of pathologic nodal positivity (pN+) in patients with microinvasive or T1a disease is poorly characterized and the value of sentinel node biopsy remains con...
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| Veröffentlicht in: | Annals of surgical oncology 2024-12, Vol.31 (13), p.8821-8828 |
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| creator | Dey, Pranam Kc, Madhav Proussaloglou, Ellie M. Khubchandani, Jasmine A. Kim, Leah Zanieski, Gregory Park, Tristen Lynch, Melanie Gillego, Alyssa Valero, Monica Schneider, Eric Golshan, Mehra Greenup, Rachel A. Berger, Elizabeth R. |
| description | Background
Axillary staging in early-stage breast cancer can impact adjuvant treatment options but also has associated morbidity. The incidence of pathologic nodal positivity (pN+) in patients with microinvasive or T1a disease is poorly characterized and the value of sentinel node biopsy remains controversial.
Methods
Women with cN0 and pathologic microinvasive or T1a cancer who underwent upfront surgery were identified from the National Cancer Database. Pathologic nodal stage at the time of surgery was the primary outcome. Multivariable logistic modeling was used to assess predictors of pN+.
Results
Overall, 141,840 women were included; 139,206 had pathologic node-negative (pN0) disease and 2634 had pN+ disease. Rates of pN+ disease differed by receptor status, with the highest rates in hormone receptor-negative/human epidermal growth factor receptor 2-positive (HR−/HER2+) disease compared with triple-negative breast cancer (TNBC), HR-positive/HER2-negative (HR+/HER2−), and triple positive breast cancer. Rates of pN+ were also higher with lobular histology compared with ductal histology. Multivariable analysis demonstrated that compared with White women, Black women had higher odds of pN+ disease, and compared with women 70 years of age had higher odds of pN+ disease. Compared with women with HR+/HER2− disease, women with TNBC, triple-positive breast cancer, and HR−/HER2+ all had lower odds, and women with invasive lobular disease had higher odds compared with women with invasive ductal disease. Women with significant comorbidities also had higher odds of node positivity.
Conclusion
Over 90% of patients with clinically node-negative, microinvasive and T1a breast cancer remain pathologically node-negative following axillary staging. However, higher rates of nodal disease were found among Black patients, older patients, and patients with lobular cancer and significant comorbidities. |
| doi_str_mv | 10.1245/s10434-024-16124-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3101240199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3126204761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-e446ae1af4dcb8c1d44ee1eecb708c0031f6fd128e0e854d10c05aa9162223b43</originalsourceid><addsrcrecordid>eNp9kU1PIzEMhiMEonz9AQ6rSFz2wICdZNKZI1vYXSS-DuUcpRlPN2g6gWSKxL8npcBKHDjFsR-_if0ydohwgkKVpwlBSVWAUAXqnCnqDbaDZU4pXeFmjkFXRS10OWK7KT0A4FhCuc1GshYKZK12WHvZO99Q74iHlt_Z4V_owtw7fhMa2_Fzn8gm4r7nk8733tmue1nVqLihuR38Mx3za-9i8P2zTfnKQ-RTtPxXzI0Dn9gsHdM-22ptl-jg_dxj978vppO_xdXtn8vJ2VXhRKmHgpTSltC2qnGzymGjFBESudkYKgcgsdVtg6IioKpUDYKD0toatRBCzpTcYz_Xuo8xPC0pDWbhk6Ousz2FZTISIS8KsK4zevQFfQjL2OffZUpoAWqsMVNiTeURU4rUmsfoFza-GASzcsGsXTDZBfPmgllJ_3iXXs4W1Hy2fKw9A3INpFzq5xT_v_2N7CscKZFe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126204761</pqid></control><display><type>article</type><title>Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dey, Pranam ; Kc, Madhav ; Proussaloglou, Ellie M. ; Khubchandani, Jasmine A. ; Kim, Leah ; Zanieski, Gregory ; Park, Tristen ; Lynch, Melanie ; Gillego, Alyssa ; Valero, Monica ; Schneider, Eric ; Golshan, Mehra ; Greenup, Rachel A. ; Berger, Elizabeth R.</creator><creatorcontrib>Dey, Pranam ; Kc, Madhav ; Proussaloglou, Ellie M. ; Khubchandani, Jasmine A. ; Kim, Leah ; Zanieski, Gregory ; Park, Tristen ; Lynch, Melanie ; Gillego, Alyssa ; Valero, Monica ; Schneider, Eric ; Golshan, Mehra ; Greenup, Rachel A. ; Berger, Elizabeth R.</creatorcontrib><description>Background
Axillary staging in early-stage breast cancer can impact adjuvant treatment options but also has associated morbidity. The incidence of pathologic nodal positivity (pN+) in patients with microinvasive or T1a disease is poorly characterized and the value of sentinel node biopsy remains controversial.
Methods
Women with cN0 and pathologic microinvasive or T1a cancer who underwent upfront surgery were identified from the National Cancer Database. Pathologic nodal stage at the time of surgery was the primary outcome. Multivariable logistic modeling was used to assess predictors of pN+.
Results
Overall, 141,840 women were included; 139,206 had pathologic node-negative (pN0) disease and 2634 had pN+ disease. Rates of pN+ disease differed by receptor status, with the highest rates in hormone receptor-negative/human epidermal growth factor receptor 2-positive (HR−/HER2+) disease compared with triple-negative breast cancer (TNBC), HR-positive/HER2-negative (HR+/HER2−), and triple positive breast cancer. Rates of pN+ were also higher with lobular histology compared with ductal histology. Multivariable analysis demonstrated that compared with White women, Black women had higher odds of pN+ disease, and compared with women <50 years of age, women >70 years of age had higher odds of pN+ disease. Compared with women with HR+/HER2− disease, women with TNBC, triple-positive breast cancer, and HR−/HER2+ all had lower odds, and women with invasive lobular disease had higher odds compared with women with invasive ductal disease. Women with significant comorbidities also had higher odds of node positivity.
Conclusion
Over 90% of patients with clinically node-negative, microinvasive and T1a breast cancer remain pathologically node-negative following axillary staging. However, higher rates of nodal disease were found among Black patients, older patients, and patients with lobular cancer and significant comorbidities.</description><identifier>ISSN: 1068-9265</identifier><identifier>ISSN: 1534-4681</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-024-16124-9</identifier><identifier>PMID: 39240394</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Axilla ; Biopsy ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Breast Oncology ; Carcinoma, Ductal, Breast - epidemiology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - surgery ; Carcinoma, Lobular - epidemiology ; Carcinoma, Lobular - metabolism ; Carcinoma, Lobular - pathology ; Carcinoma, Lobular - surgery ; Comorbidity ; ErbB-2 protein ; Female ; Follow-Up Studies ; Histology ; Humans ; Incidence ; Invasiveness ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Medicine ; Medicine & Public Health ; Middle Aged ; Morbidity ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Patients ; Prognosis ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Sentinel Lymph Node Biopsy ; Surgery ; Surgical Oncology ; Triple Negative Breast Neoplasms - epidemiology ; Triple Negative Breast Neoplasms - metabolism ; Triple Negative Breast Neoplasms - pathology ; Triple Negative Breast Neoplasms - surgery ; Womens health</subject><ispartof>Annals of surgical oncology, 2024-12, Vol.31 (13), p.8821-8828</ispartof><rights>Society of Surgical Oncology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Society of Surgical Oncology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-e446ae1af4dcb8c1d44ee1eecb708c0031f6fd128e0e854d10c05aa9162223b43</cites><orcidid>0000-0001-9556-9766</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-024-16124-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-024-16124-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39240394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dey, Pranam</creatorcontrib><creatorcontrib>Kc, Madhav</creatorcontrib><creatorcontrib>Proussaloglou, Ellie M.</creatorcontrib><creatorcontrib>Khubchandani, Jasmine A.</creatorcontrib><creatorcontrib>Kim, Leah</creatorcontrib><creatorcontrib>Zanieski, Gregory</creatorcontrib><creatorcontrib>Park, Tristen</creatorcontrib><creatorcontrib>Lynch, Melanie</creatorcontrib><creatorcontrib>Gillego, Alyssa</creatorcontrib><creatorcontrib>Valero, Monica</creatorcontrib><creatorcontrib>Schneider, Eric</creatorcontrib><creatorcontrib>Golshan, Mehra</creatorcontrib><creatorcontrib>Greenup, Rachel A.</creatorcontrib><creatorcontrib>Berger, Elizabeth R.</creatorcontrib><title>Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Axillary staging in early-stage breast cancer can impact adjuvant treatment options but also has associated morbidity. The incidence of pathologic nodal positivity (pN+) in patients with microinvasive or T1a disease is poorly characterized and the value of sentinel node biopsy remains controversial.
Methods
Women with cN0 and pathologic microinvasive or T1a cancer who underwent upfront surgery were identified from the National Cancer Database. Pathologic nodal stage at the time of surgery was the primary outcome. Multivariable logistic modeling was used to assess predictors of pN+.
Results
Overall, 141,840 women were included; 139,206 had pathologic node-negative (pN0) disease and 2634 had pN+ disease. Rates of pN+ disease differed by receptor status, with the highest rates in hormone receptor-negative/human epidermal growth factor receptor 2-positive (HR−/HER2+) disease compared with triple-negative breast cancer (TNBC), HR-positive/HER2-negative (HR+/HER2−), and triple positive breast cancer. Rates of pN+ were also higher with lobular histology compared with ductal histology. Multivariable analysis demonstrated that compared with White women, Black women had higher odds of pN+ disease, and compared with women <50 years of age, women >70 years of age had higher odds of pN+ disease. Compared with women with HR+/HER2− disease, women with TNBC, triple-positive breast cancer, and HR−/HER2+ all had lower odds, and women with invasive lobular disease had higher odds compared with women with invasive ductal disease. Women with significant comorbidities also had higher odds of node positivity.
Conclusion
Over 90% of patients with clinically node-negative, microinvasive and T1a breast cancer remain pathologically node-negative following axillary staging. However, higher rates of nodal disease were found among Black patients, older patients, and patients with lobular cancer and significant comorbidities.</description><subject>Adult</subject><subject>Aged</subject><subject>Axilla</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Breast Oncology</subject><subject>Carcinoma, Ductal, Breast - epidemiology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - surgery</subject><subject>Carcinoma, Lobular - epidemiology</subject><subject>Carcinoma, Lobular - metabolism</subject><subject>Carcinoma, Lobular - pathology</subject><subject>Carcinoma, Lobular - surgery</subject><subject>Comorbidity</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Histology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Invasiveness</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Triple Negative Breast Neoplasms - epidemiology</subject><subject>Triple Negative Breast Neoplasms - metabolism</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><subject>Triple Negative Breast Neoplasms - surgery</subject><subject>Womens health</subject><issn>1068-9265</issn><issn>1534-4681</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1PIzEMhiMEonz9AQ6rSFz2wICdZNKZI1vYXSS-DuUcpRlPN2g6gWSKxL8npcBKHDjFsR-_if0ydohwgkKVpwlBSVWAUAXqnCnqDbaDZU4pXeFmjkFXRS10OWK7KT0A4FhCuc1GshYKZK12WHvZO99Q74iHlt_Z4V_owtw7fhMa2_Fzn8gm4r7nk8733tmue1nVqLihuR38Mx3za-9i8P2zTfnKQ-RTtPxXzI0Dn9gsHdM-22ptl-jg_dxj978vppO_xdXtn8vJ2VXhRKmHgpTSltC2qnGzymGjFBESudkYKgcgsdVtg6IioKpUDYKD0toatRBCzpTcYz_Xuo8xPC0pDWbhk6Ousz2FZTISIS8KsK4zevQFfQjL2OffZUpoAWqsMVNiTeURU4rUmsfoFza-GASzcsGsXTDZBfPmgllJ_3iXXs4W1Hy2fKw9A3INpFzq5xT_v_2N7CscKZFe</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Dey, Pranam</creator><creator>Kc, Madhav</creator><creator>Proussaloglou, Ellie M.</creator><creator>Khubchandani, Jasmine A.</creator><creator>Kim, Leah</creator><creator>Zanieski, Gregory</creator><creator>Park, Tristen</creator><creator>Lynch, Melanie</creator><creator>Gillego, Alyssa</creator><creator>Valero, Monica</creator><creator>Schneider, Eric</creator><creator>Golshan, Mehra</creator><creator>Greenup, Rachel A.</creator><creator>Berger, Elizabeth R.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9556-9766</orcidid></search><sort><creationdate>20241201</creationdate><title>Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers</title><author>Dey, Pranam ; Kc, Madhav ; Proussaloglou, Ellie M. ; Khubchandani, Jasmine A. ; Kim, Leah ; Zanieski, Gregory ; Park, Tristen ; Lynch, Melanie ; Gillego, Alyssa ; Valero, Monica ; Schneider, Eric ; Golshan, Mehra ; Greenup, Rachel A. ; Berger, Elizabeth R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-e446ae1af4dcb8c1d44ee1eecb708c0031f6fd128e0e854d10c05aa9162223b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axilla</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Breast Oncology</topic><topic>Carcinoma, Ductal, Breast - epidemiology</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - surgery</topic><topic>Carcinoma, Lobular - epidemiology</topic><topic>Carcinoma, Lobular - metabolism</topic><topic>Carcinoma, Lobular - pathology</topic><topic>Carcinoma, Lobular - surgery</topic><topic>Comorbidity</topic><topic>ErbB-2 protein</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Histology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Invasiveness</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Triple Negative Breast Neoplasms - epidemiology</topic><topic>Triple Negative Breast Neoplasms - metabolism</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><topic>Triple Negative Breast Neoplasms - surgery</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dey, Pranam</creatorcontrib><creatorcontrib>Kc, Madhav</creatorcontrib><creatorcontrib>Proussaloglou, Ellie M.</creatorcontrib><creatorcontrib>Khubchandani, Jasmine A.</creatorcontrib><creatorcontrib>Kim, Leah</creatorcontrib><creatorcontrib>Zanieski, Gregory</creatorcontrib><creatorcontrib>Park, Tristen</creatorcontrib><creatorcontrib>Lynch, Melanie</creatorcontrib><creatorcontrib>Gillego, Alyssa</creatorcontrib><creatorcontrib>Valero, Monica</creatorcontrib><creatorcontrib>Schneider, Eric</creatorcontrib><creatorcontrib>Golshan, Mehra</creatorcontrib><creatorcontrib>Greenup, Rachel A.</creatorcontrib><creatorcontrib>Berger, Elizabeth R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dey, Pranam</au><au>Kc, Madhav</au><au>Proussaloglou, Ellie M.</au><au>Khubchandani, Jasmine A.</au><au>Kim, Leah</au><au>Zanieski, Gregory</au><au>Park, Tristen</au><au>Lynch, Melanie</au><au>Gillego, Alyssa</au><au>Valero, Monica</au><au>Schneider, Eric</au><au>Golshan, Mehra</au><au>Greenup, Rachel A.</au><au>Berger, Elizabeth R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>31</volume><issue>13</issue><spage>8821</spage><epage>8828</epage><pages>8821-8828</pages><issn>1068-9265</issn><issn>1534-4681</issn><eissn>1534-4681</eissn><abstract>Background
Axillary staging in early-stage breast cancer can impact adjuvant treatment options but also has associated morbidity. The incidence of pathologic nodal positivity (pN+) in patients with microinvasive or T1a disease is poorly characterized and the value of sentinel node biopsy remains controversial.
Methods
Women with cN0 and pathologic microinvasive or T1a cancer who underwent upfront surgery were identified from the National Cancer Database. Pathologic nodal stage at the time of surgery was the primary outcome. Multivariable logistic modeling was used to assess predictors of pN+.
Results
Overall, 141,840 women were included; 139,206 had pathologic node-negative (pN0) disease and 2634 had pN+ disease. Rates of pN+ disease differed by receptor status, with the highest rates in hormone receptor-negative/human epidermal growth factor receptor 2-positive (HR−/HER2+) disease compared with triple-negative breast cancer (TNBC), HR-positive/HER2-negative (HR+/HER2−), and triple positive breast cancer. Rates of pN+ were also higher with lobular histology compared with ductal histology. Multivariable analysis demonstrated that compared with White women, Black women had higher odds of pN+ disease, and compared with women <50 years of age, women >70 years of age had higher odds of pN+ disease. Compared with women with HR+/HER2− disease, women with TNBC, triple-positive breast cancer, and HR−/HER2+ all had lower odds, and women with invasive lobular disease had higher odds compared with women with invasive ductal disease. Women with significant comorbidities also had higher odds of node positivity.
Conclusion
Over 90% of patients with clinically node-negative, microinvasive and T1a breast cancer remain pathologically node-negative following axillary staging. However, higher rates of nodal disease were found among Black patients, older patients, and patients with lobular cancer and significant comorbidities.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39240394</pmid><doi>10.1245/s10434-024-16124-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9556-9766</orcidid></addata></record> |
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| ispartof | Annals of surgical oncology, 2024-12, Vol.31 (13), p.8821-8828 |
| issn | 1068-9265 1534-4681 1534-4681 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Axilla Biopsy Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - surgery Breast Oncology Carcinoma, Ductal, Breast - epidemiology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - surgery Carcinoma, Lobular - epidemiology Carcinoma, Lobular - metabolism Carcinoma, Lobular - pathology Carcinoma, Lobular - surgery Comorbidity ErbB-2 protein Female Follow-Up Studies Histology Humans Incidence Invasiveness Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Medicine Medicine & Public Health Middle Aged Morbidity Neoplasm Invasiveness Neoplasm Staging Oncology Patients Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sentinel Lymph Node Biopsy Surgery Surgical Oncology Triple Negative Breast Neoplasms - epidemiology Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Triple Negative Breast Neoplasms - surgery Womens health |
| title | Incidence of Pathologic Nodal Disease in Clinically Node-Negative, Microinvasive or T1a Breast Cancers |
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