Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies

Alzheimer’s disease (AD) is the leading cause of dementia among the elderly population, posing a significant public health challenge due to limited therapeutic options that merely delay cognitive decline. AD is associated with impaired energy metabolism and reduced neurotrophic signaling. The insuli...

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Veröffentlicht in:	Molecular neurobiology 2025-03, Vol.62 (3), p.3195-3225
Hauptverfasser:	Miao, Jie, Zhang, Yanli, Su, Chen, Zheng, Qiandan, Guo, Junhong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Animals Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Cognitive ability Dementia disorders Energy metabolism Humans Insulin Insulin-like growth factor I Insulin-like growth factor I receptors Insulin-like growth factors Insulin-Like Peptides Kinases MAP kinase Metabolism Molecular modelling Neurobiology Neurodegenerative diseases Neurology Neurosciences Older people Pathophysiology Public health Review Signal Transduction Somatomedins - metabolism
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