Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19

Background The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into pathogenesis and potential therapeutic targets. Objective This study aimed to invest...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2024-01, Vol.38, p.3946320241279893
Hauptverfasser:	Benmansour, R., Tagajdid, M. R., Lahlou, I. A, Oumzil, H., El Hamzaoui, H., Fjouji, S., Doghmi, N., Houba, A., Elkochri, S., Aabi, R., Elannaz, H., Laraqui, A., El Mchichi, B., Touil, N., Ennibi, K., Bouhouche, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Case-Control Studies Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - immunology COVID-19 - virology Cytokines Female Genetic factors Genetic Predisposition to Disease Humans Infections Interleukin 12 Interleukin 6 Interleukin-12 Subunit p35 - genetics Interleukin-12 Subunit p40 - genetics Interleukin-6 - genetics Male Middle Aged Morbidity Morocco Next-generation sequencing Polymorphism, Single Nucleotide Regression analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Single-nucleotide polymorphism Statistical analysis Statistical models Susceptibility Therapeutic targets Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF
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