Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls
To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA). The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2024-12, Vol.189, p.117250, Article 117250 |
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| creator | Watanabe, Kounosuke Chiba, Ko Shiraishi, Kazuteru Iida, Takeshi Iwamoto, Naoki Yonekura, Akihiko Kawakami, Atsushi Osaki, Makoto |
| description | To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA).
The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.
There were no differences in joint space parameters between RA patients and HCs.
For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm3), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm3) than HCs.
Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm3), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.
Most of the erosions in HCs were |
| doi_str_mv | 10.1016/j.bone.2024.117250 |
| format | Article |
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The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.
There were no differences in joint space parameters between RA patients and HCs.
For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm3), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm3) than HCs.
Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm3), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.
Most of the erosions in HCs were <5 mm3 in volume (95 %) and located on the radial side (85 %). When erosions <5 mm3 were compared between RA patients and HCs, there were no differences in their location or morphology.
Deterioration of bone microarchitecture and existences of erosions >5 mm3 in the MCP joints are sensitive imaging markers of RA. Erosions <5 mm3 in RA patients may include not only early pathological erosion but also physiological erosion because even HCs can have erosions <5 mm3.
•Morphological parameters by HR-pQCT that sensitively differentiate RA were investigated.•Deterioration of bone microarchitecture was sensitive imaging marker of RA.•Erosions >5 mm3 was also sensitive imaging marker of RA.•Erosions <5 mm3 may include not only early pathological erosion but physiological erosion.</description><identifier>ISSN: 8756-3282</identifier><identifier>ISSN: 1873-2763</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2024.117250</identifier><identifier>PMID: 39237048</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - pathology ; Bone Density ; Bone microarchitecture ; Case-Control Studies ; Erosion ; Female ; High-resolution peripheral quantitative computed tomography ; Humans ; Joint space ; Male ; Metacarpophalangeal Joint - diagnostic imaging ; Metacarpophalangeal Joint - pathology ; Middle Aged ; Rheumatoid arthritis ; Tomography, X-Ray Computed - methods</subject><ispartof>Bone (New York, N.Y.), 2024-12, Vol.189, p.117250, Article 117250</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-9d2c62fd072b463860f7495fd2aacfa5684eaf9bf5f01e3fd1446c408e9401973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2024.117250$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39237048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Kounosuke</creatorcontrib><creatorcontrib>Chiba, Ko</creatorcontrib><creatorcontrib>Shiraishi, Kazuteru</creatorcontrib><creatorcontrib>Iida, Takeshi</creatorcontrib><creatorcontrib>Iwamoto, Naoki</creatorcontrib><creatorcontrib>Yonekura, Akihiko</creatorcontrib><creatorcontrib>Kawakami, Atsushi</creatorcontrib><creatorcontrib>Osaki, Makoto</creatorcontrib><title>Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA).
The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.
There were no differences in joint space parameters between RA patients and HCs.
For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm3), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm3) than HCs.
Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm3), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.
Most of the erosions in HCs were <5 mm3 in volume (95 %) and located on the radial side (85 %). When erosions <5 mm3 were compared between RA patients and HCs, there were no differences in their location or morphology.
Deterioration of bone microarchitecture and existences of erosions >5 mm3 in the MCP joints are sensitive imaging markers of RA. Erosions <5 mm3 in RA patients may include not only early pathological erosion but also physiological erosion because even HCs can have erosions <5 mm3.
•Morphological parameters by HR-pQCT that sensitively differentiate RA were investigated.•Deterioration of bone microarchitecture was sensitive imaging marker of RA.•Erosions >5 mm3 was also sensitive imaging marker of RA.•Erosions <5 mm3 may include not only early pathological erosion but physiological erosion.</description><subject>Aged</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Bone Density</subject><subject>Bone microarchitecture</subject><subject>Case-Control Studies</subject><subject>Erosion</subject><subject>Female</subject><subject>High-resolution peripheral quantitative computed tomography</subject><subject>Humans</subject><subject>Joint space</subject><subject>Male</subject><subject>Metacarpophalangeal Joint - diagnostic imaging</subject><subject>Metacarpophalangeal Joint - pathology</subject><subject>Middle Aged</subject><subject>Rheumatoid arthritis</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>8756-3282</issn><issn>1873-2763</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAURi1ERaeFF2CBvGSTwX-JE8SmGkGL1AqBytryONeNR4kdbAc079EHxqMUll1Zujr3k-93EHpLyZYS2nw4bPfBw5YRJraUSlaTF2hDW8krJhv-Em1aWTcVZy07RxcpHQghvJP0FTrnHeOSiHaDHu-ciUFHM7gMJi9Rj1h7PR6TSzhYnAfAE2RtdJzDPOhR-wcozCE4n_GSnH_ANz-q-fvuHjuPZ50d-JzwH5cHHAdYJp2D67GOeYguu_QRX2ETpllHl4JfuaEk5uFY5j7HMKbX6MzqMcGbp_cS_fzy-X53U91-u_66u7qtTPl-rrqemYbZnki2Fw1vG2Kl6GrbM62N1XXTCtC229vaEgrc9lSIxgjSQicI7SS_RO_X3DmGXwukrCaXDIzlSAhLUrzUzDiTdVdQtqKlrZQiWDVHN-l4VJSokw11UCcb6mRDrTbK0run_GU_Qf9_5V_9Bfi0AlCu_O0gqmRKfwZ6F4sN1Qf3XP5fxkqevg</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Watanabe, Kounosuke</creator><creator>Chiba, Ko</creator><creator>Shiraishi, Kazuteru</creator><creator>Iida, Takeshi</creator><creator>Iwamoto, Naoki</creator><creator>Yonekura, Akihiko</creator><creator>Kawakami, Atsushi</creator><creator>Osaki, Makoto</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls</title><author>Watanabe, Kounosuke ; Chiba, Ko ; Shiraishi, Kazuteru ; Iida, Takeshi ; Iwamoto, Naoki ; Yonekura, Akihiko ; Kawakami, Atsushi ; Osaki, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-9d2c62fd072b463860f7495fd2aacfa5684eaf9bf5f01e3fd1446c408e9401973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Bone Density</topic><topic>Bone microarchitecture</topic><topic>Case-Control Studies</topic><topic>Erosion</topic><topic>Female</topic><topic>High-resolution peripheral quantitative computed tomography</topic><topic>Humans</topic><topic>Joint space</topic><topic>Male</topic><topic>Metacarpophalangeal Joint - diagnostic imaging</topic><topic>Metacarpophalangeal Joint - pathology</topic><topic>Middle Aged</topic><topic>Rheumatoid arthritis</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Kounosuke</creatorcontrib><creatorcontrib>Chiba, Ko</creatorcontrib><creatorcontrib>Shiraishi, Kazuteru</creatorcontrib><creatorcontrib>Iida, Takeshi</creatorcontrib><creatorcontrib>Iwamoto, Naoki</creatorcontrib><creatorcontrib>Yonekura, Akihiko</creatorcontrib><creatorcontrib>Kawakami, Atsushi</creatorcontrib><creatorcontrib>Osaki, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Kounosuke</au><au>Chiba, Ko</au><au>Shiraishi, Kazuteru</au><au>Iida, Takeshi</au><au>Iwamoto, Naoki</au><au>Yonekura, Akihiko</au><au>Kawakami, Atsushi</au><au>Osaki, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2024-12</date><risdate>2024</risdate><volume>189</volume><spage>117250</spage><pages>117250-</pages><artnum>117250</artnum><issn>8756-3282</issn><issn>1873-2763</issn><eissn>1873-2763</eissn><abstract>To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA).
The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.
There were no differences in joint space parameters between RA patients and HCs.
For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm3), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm3) than HCs.
Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm3), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.
Most of the erosions in HCs were <5 mm3 in volume (95 %) and located on the radial side (85 %). When erosions <5 mm3 were compared between RA patients and HCs, there were no differences in their location or morphology.
Deterioration of bone microarchitecture and existences of erosions >5 mm3 in the MCP joints are sensitive imaging markers of RA. Erosions <5 mm3 in RA patients may include not only early pathological erosion but also physiological erosion because even HCs can have erosions <5 mm3.
•Morphological parameters by HR-pQCT that sensitively differentiate RA were investigated.•Deterioration of bone microarchitecture was sensitive imaging marker of RA.•Erosions >5 mm3 was also sensitive imaging marker of RA.•Erosions <5 mm3 may include not only early pathological erosion but physiological erosion.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39237048</pmid><doi>10.1016/j.bone.2024.117250</doi></addata></record> |
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| subjects | Aged Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - pathology Bone Density Bone microarchitecture Case-Control Studies Erosion Female High-resolution peripheral quantitative computed tomography Humans Joint space Male Metacarpophalangeal Joint - diagnostic imaging Metacarpophalangeal Joint - pathology Middle Aged Rheumatoid arthritis Tomography, X-Ray Computed - methods |
| title | Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls |
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