The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity
Purpose To assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results which were used for detecting early retinal changes in patients using oral hydroxychloroquine. Methods Patients using oral hydroxychloroquine for a...
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| Veröffentlicht in: | International ophthalmology 2024-09, Vol.44 (1), p.370, Article 370 |
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| creator | Sonalcan, Vildan Çakir, Burçin Özkan Aksoy, Nilgün Özata Gündoğdu, Kübra Türkoğlu Şen, Elif Betül Alagöz, Gürsoy |
| description | Purpose
To assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results which were used for detecting early retinal changes in patients using oral hydroxychloroquine.
Methods
Patients using oral hydroxychloroquine for at least one year were divided into two groups according to the duration of drug use. Groups 1 and 2 consisted of patients with drug use for more than 5 years and 1–5 years, respectively. The drug-using groups were compared with the control group. The mean retinal nerve fiber layer (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer (GC-IPL), static 10–2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.
Results
Median and temporal quadrant RNFL thicknesses were found to be statistically significantly lower in the drug groups. In the drug groups, the GC-IPL sectoral and mean thicknesses were found to be statistically lower in all quadrants. Central macular thickness was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. Macular FAF images were significantly higher in the drug users, but there was no significant difference between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the drug groups than in the control group at all spatial frequencies except 6 and 18 cycles/degree.
Conclusions
The combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes. |
| doi_str_mv | 10.1007/s10792-024-03296-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3101232683</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3100997842</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-698d4c91da0b302563bcd5a4523287c6767d7e0d07c6eae87d22be68f9b8e583</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS1UREvhC3CoLPXSS8CxN_5zrKoWkCpx2bvl2BM2VRK3Hltqvj3e3QIVB04ee37veUaPkE8t-9wypr5gy5ThDeObhgluZMPfkLO2U6LhUrCTV_UpeY_4wBgzysh35FQYLpTm4ozgdgfUIQLiDEumcaCYU_G5JDdRtwQ6lMXnMS71mgEzTYBlykiHmCi4NK00QIYDslfv1pDi8-p3U0zxqYwL0Nn5MrlEc3we_ZjXD-Tt4CaEjy_nOdne3W5vvjX3P75-v7m-bzzvZG6k0WHjTRsc6wWrT6L3oXObjguulZdKqqCABVZrcKBV4LwHqQfTa-i0OCdXR9vH_SB1dDuP6GGa3AKxoBUta6uV1KKil_-gD7GkuvKBYsYoveGV4kfKp4iYYLCPaZxdWm3L7D4Re0zE1kTsIRG7F128WJd-hvBH8juCCogjgLW1_IT09-__2P4CaJmYrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3100997842</pqid></control><display><type>article</type><title>The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Sonalcan, Vildan ; Çakir, Burçin ; Özkan Aksoy, Nilgün ; Özata Gündoğdu, Kübra ; Türkoğlu Şen, Elif Betül ; Alagöz, Gürsoy</creator><creatorcontrib>Sonalcan, Vildan ; Çakir, Burçin ; Özkan Aksoy, Nilgün ; Özata Gündoğdu, Kübra ; Türkoğlu Şen, Elif Betül ; Alagöz, Gürsoy</creatorcontrib><description>Purpose
To assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results which were used for detecting early retinal changes in patients using oral hydroxychloroquine.
Methods
Patients using oral hydroxychloroquine for at least one year were divided into two groups according to the duration of drug use. Groups 1 and 2 consisted of patients with drug use for more than 5 years and 1–5 years, respectively. The drug-using groups were compared with the control group. The mean retinal nerve fiber layer (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer (GC-IPL), static 10–2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.
Results
Median and temporal quadrant RNFL thicknesses were found to be statistically significantly lower in the drug groups. In the drug groups, the GC-IPL sectoral and mean thicknesses were found to be statistically lower in all quadrants. Central macular thickness was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. Macular FAF images were significantly higher in the drug users, but there was no significant difference between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the drug groups than in the control group at all spatial frequencies except 6 and 18 cycles/degree.
Conclusions
The combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-024-03296-2</identifier><identifier>PMID: 39237823</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Antirheumatic Agents - adverse effects ; Contrast Sensitivity - drug effects ; Contrast Sensitivity - physiology ; Drug abuse ; Drug use ; Early Diagnosis ; Female ; Fluorescein Angiography - methods ; Functional testing ; Humans ; Hydroxychloroquine ; Hydroxychloroquine - adverse effects ; Image contrast ; Macula Lutea - diagnostic imaging ; Macula Lutea - drug effects ; Macula Lutea - pathology ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Nerve Fibers - drug effects ; Nerve Fibers - pathology ; Ophthalmology ; Original Paper ; Parameter sensitivity ; Quadrants ; Retina ; Retinal Diseases - chemically induced ; Retinal Diseases - diagnosis ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - pathology ; Sensitivity analysis ; Statistical analysis ; Structure-function relationships ; Thickness ; Tomography, Optical Coherence - methods ; Toxicity ; Toxicity testing ; Visual Acuity ; Visual field ; Visual Field Tests - methods ; Visual fields ; Visual Fields - drug effects ; Visual Fields - physiology</subject><ispartof>International ophthalmology, 2024-09, Vol.44 (1), p.370, Article 370</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-698d4c91da0b302563bcd5a4523287c6767d7e0d07c6eae87d22be68f9b8e583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-024-03296-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-024-03296-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39237823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonalcan, Vildan</creatorcontrib><creatorcontrib>Çakir, Burçin</creatorcontrib><creatorcontrib>Özkan Aksoy, Nilgün</creatorcontrib><creatorcontrib>Özata Gündoğdu, Kübra</creatorcontrib><creatorcontrib>Türkoğlu Şen, Elif Betül</creatorcontrib><creatorcontrib>Alagöz, Gürsoy</creatorcontrib><title>The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results which were used for detecting early retinal changes in patients using oral hydroxychloroquine.
Methods
Patients using oral hydroxychloroquine for at least one year were divided into two groups according to the duration of drug use. Groups 1 and 2 consisted of patients with drug use for more than 5 years and 1–5 years, respectively. The drug-using groups were compared with the control group. The mean retinal nerve fiber layer (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer (GC-IPL), static 10–2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.
Results
Median and temporal quadrant RNFL thicknesses were found to be statistically significantly lower in the drug groups. In the drug groups, the GC-IPL sectoral and mean thicknesses were found to be statistically lower in all quadrants. Central macular thickness was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. Macular FAF images were significantly higher in the drug users, but there was no significant difference between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the drug groups than in the control group at all spatial frequencies except 6 and 18 cycles/degree.
Conclusions
The combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes.</description><subject>Adult</subject><subject>Aged</subject><subject>Antirheumatic Agents - adverse effects</subject><subject>Contrast Sensitivity - drug effects</subject><subject>Contrast Sensitivity - physiology</subject><subject>Drug abuse</subject><subject>Drug use</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Functional testing</subject><subject>Humans</subject><subject>Hydroxychloroquine</subject><subject>Hydroxychloroquine - adverse effects</subject><subject>Image contrast</subject><subject>Macula Lutea - diagnostic imaging</subject><subject>Macula Lutea - drug effects</subject><subject>Macula Lutea - pathology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Parameter sensitivity</subject><subject>Quadrants</subject><subject>Retina</subject><subject>Retinal Diseases - chemically induced</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Sensitivity analysis</subject><subject>Statistical analysis</subject><subject>Structure-function relationships</subject><subject>Thickness</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Toxicity</subject><subject>Toxicity testing</subject><subject>Visual Acuity</subject><subject>Visual field</subject><subject>Visual Field Tests - methods</subject><subject>Visual fields</subject><subject>Visual Fields - drug effects</subject><subject>Visual Fields - physiology</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS1UREvhC3CoLPXSS8CxN_5zrKoWkCpx2bvl2BM2VRK3Hltqvj3e3QIVB04ee37veUaPkE8t-9wypr5gy5ThDeObhgluZMPfkLO2U6LhUrCTV_UpeY_4wBgzysh35FQYLpTm4ozgdgfUIQLiDEumcaCYU_G5JDdRtwQ6lMXnMS71mgEzTYBlykiHmCi4NK00QIYDslfv1pDi8-p3U0zxqYwL0Nn5MrlEc3we_ZjXD-Tt4CaEjy_nOdne3W5vvjX3P75-v7m-bzzvZG6k0WHjTRsc6wWrT6L3oXObjguulZdKqqCABVZrcKBV4LwHqQfTa-i0OCdXR9vH_SB1dDuP6GGa3AKxoBUta6uV1KKil_-gD7GkuvKBYsYoveGV4kfKp4iYYLCPaZxdWm3L7D4Re0zE1kTsIRG7F128WJd-hvBH8juCCogjgLW1_IT09-__2P4CaJmYrg</recordid><startdate>20240906</startdate><enddate>20240906</enddate><creator>Sonalcan, Vildan</creator><creator>Çakir, Burçin</creator><creator>Özkan Aksoy, Nilgün</creator><creator>Özata Gündoğdu, Kübra</creator><creator>Türkoğlu Şen, Elif Betül</creator><creator>Alagöz, Gürsoy</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240906</creationdate><title>The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity</title><author>Sonalcan, Vildan ; Çakir, Burçin ; Özkan Aksoy, Nilgün ; Özata Gündoğdu, Kübra ; Türkoğlu Şen, Elif Betül ; Alagöz, Gürsoy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-698d4c91da0b302563bcd5a4523287c6767d7e0d07c6eae87d22be68f9b8e583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antirheumatic Agents - adverse effects</topic><topic>Contrast Sensitivity - drug effects</topic><topic>Contrast Sensitivity - physiology</topic><topic>Drug abuse</topic><topic>Drug use</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Functional testing</topic><topic>Humans</topic><topic>Hydroxychloroquine</topic><topic>Hydroxychloroquine - adverse effects</topic><topic>Image contrast</topic><topic>Macula Lutea - diagnostic imaging</topic><topic>Macula Lutea - drug effects</topic><topic>Macula Lutea - pathology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Parameter sensitivity</topic><topic>Quadrants</topic><topic>Retina</topic><topic>Retinal Diseases - chemically induced</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Ganglion Cells - drug effects</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Sensitivity analysis</topic><topic>Statistical analysis</topic><topic>Structure-function relationships</topic><topic>Thickness</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Toxicity</topic><topic>Toxicity testing</topic><topic>Visual Acuity</topic><topic>Visual field</topic><topic>Visual Field Tests - methods</topic><topic>Visual fields</topic><topic>Visual Fields - drug effects</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonalcan, Vildan</creatorcontrib><creatorcontrib>Çakir, Burçin</creatorcontrib><creatorcontrib>Özkan Aksoy, Nilgün</creatorcontrib><creatorcontrib>Özata Gündoğdu, Kübra</creatorcontrib><creatorcontrib>Türkoğlu Şen, Elif Betül</creatorcontrib><creatorcontrib>Alagöz, Gürsoy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonalcan, Vildan</au><au>Çakir, Burçin</au><au>Özkan Aksoy, Nilgün</au><au>Özata Gündoğdu, Kübra</au><au>Türkoğlu Şen, Elif Betül</au><au>Alagöz, Gürsoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2024-09-06</date><risdate>2024</risdate><volume>44</volume><issue>1</issue><spage>370</spage><pages>370-</pages><artnum>370</artnum><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results which were used for detecting early retinal changes in patients using oral hydroxychloroquine.
Methods
Patients using oral hydroxychloroquine for at least one year were divided into two groups according to the duration of drug use. Groups 1 and 2 consisted of patients with drug use for more than 5 years and 1–5 years, respectively. The drug-using groups were compared with the control group. The mean retinal nerve fiber layer (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer (GC-IPL), static 10–2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.
Results
Median and temporal quadrant RNFL thicknesses were found to be statistically significantly lower in the drug groups. In the drug groups, the GC-IPL sectoral and mean thicknesses were found to be statistically lower in all quadrants. Central macular thickness was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. Macular FAF images were significantly higher in the drug users, but there was no significant difference between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the drug groups than in the control group at all spatial frequencies except 6 and 18 cycles/degree.
Conclusions
The combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39237823</pmid><doi>10.1007/s10792-024-03296-2</doi></addata></record> |
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| subjects | Adult Aged Antirheumatic Agents - adverse effects Contrast Sensitivity - drug effects Contrast Sensitivity - physiology Drug abuse Drug use Early Diagnosis Female Fluorescein Angiography - methods Functional testing Humans Hydroxychloroquine Hydroxychloroquine - adverse effects Image contrast Macula Lutea - diagnostic imaging Macula Lutea - drug effects Macula Lutea - pathology Male Medical imaging Medicine Medicine & Public Health Middle Aged Nerve Fibers - drug effects Nerve Fibers - pathology Ophthalmology Original Paper Parameter sensitivity Quadrants Retina Retinal Diseases - chemically induced Retinal Diseases - diagnosis Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - pathology Sensitivity analysis Statistical analysis Structure-function relationships Thickness Tomography, Optical Coherence - methods Toxicity Toxicity testing Visual Acuity Visual field Visual Field Tests - methods Visual fields Visual Fields - drug effects Visual Fields - physiology |
| title | The assessment of structural and functional test results for early detection of hydroxychloroquine macular toxicity |
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