Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages

While the acute inflammatory response to harmful stimuli is protective, unrestrained neutrophil swarming drives collateral tissue damage and inflammation. Biosynthesized from omega-3 essential polyunsaturated fatty acids, resolvins are a family of signaling molecules produced by immune cells within...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-09, Vol.121 (37), p.e2405821121
Hauptverfasser:	Nshimiyimana, Robert, Simard, Mélissa, Teder, Tarvi, Rodriguez, Ana R, Spur, Bernd W, Haeggström, Jesper Z, Serhan, Charles N
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonate 5-lipoxygenase Biosynthesis Chemical synthesis Docosahexaenoic acid Docosahexaenoic Acids - biosynthesis Docosahexaenoic Acids - metabolism Epoxide hydrolase Glutathione Glutathione transferase Homeostasis Humans Immune system Inflammation Inflammatory response Leukocytes (mononuclear) Leukocytes (neutrophilic) Leukotriene-C4 synthase Lipoxygenase Liquid chromatography Macrophages Macrophages - metabolism Mass spectrometry Mass spectroscopy Molecular docking Neutrophils Neutrophils - metabolism Peripheral blood mononuclear cells Phagocytes Polyunsaturated fatty acids Receptors, G-Protein-Coupled Regeneration (physiology) Staphylococcal enterotoxin H Swarming Tissue engineering
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