Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives

We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leis...

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Veröffentlicht in:	Chemistry & biodiversity 2025-01, Vol.22 (1), p.e202401300-n/a
Hauptverfasser:	Oliveira, Thaís A. S., Silva, Jackson B. A., Silva, Nagela B. S., Félix, Paulo C. A., Santos, Daiane A., Oliveira, Andreia M., Martins, Carlos H. G., Magalhães, Lizandra G., Crotti, Antônio E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-diidropyridine Amastigotes Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antiinfectives and antibacterials Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Bacteria Dihydropyridine Dihydropyridines - chemical synthesis Dihydropyridines - chemistry Dihydropyridines - pharmacology Dose-Response Relationship, Drug Leishmania - drug effects Leishmania amazonensis Mice Microbial Sensitivity Tests Microwave irradiation Minimum inhibitory concentration Molecular Structure Oral pathogens Parasitic Sensitivity Tests Promastigotes Streptococcus - drug effects Streptococcus mutans Structure-Activity Relationship
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