Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives
We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leis...
Gespeichert in:
| Veröffentlicht in: | Chemistry & biodiversity 2025-01, Vol.22 (1), p.e202401300-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 1 |
| container_start_page | e202401300 |
| container_title | Chemistry & biodiversity |
| container_volume | 22 |
| creator | Oliveira, Thaís A. S. Silva, Jackson B. A. Silva, Nagela B. S. Félix, Paulo C. A. Santos, Daiane A. Oliveira, Andreia M. Martins, Carlos H. G. Magalhães, Lizandra G. Crotti, Antônio E. M. |
| description | We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leishmania (L.) amazonensis promastigotes and amastigotes. Thirteen compounds were moderately active against Streptococcus sanguinis, Streptococcus mitis, and Lactobacillus paracasei. Compound 22 (diethyl 4‐(3‐methoxy‐4‐hydroxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate) displayed moderate antibacterial activity against S. mitis and S. sanguinis, with a Minimum Inhibitory Concentration (MIC) of 500 μg/mL); compounds 8 (ethyl 2,7,7‐trimethyl‐4‐(3‐chlorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 10 (ethyl 2,7,7‐trimethyl‐4‐(3‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were moderately active against S. sanguinis (MIC=500 μg/mL) and very active against L. amazonensis promastigotes (IC50=43.08 and 34.29 μM, respectively). Among the eight 1,4‐DHPs that were active (IC50 7.9 and >7.3, respectively) after 24 h of treatment. Our results indicated that asymmetric 1,4‐DHPs derived from dimedone exhibit antileishmanial potential. |
| doi_str_mv | 10.1002/cbdv.202401300 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3100914514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3100914514</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2580-802efb99eaf18df0d97d1b54183c987be691368438e7900cc452c3ac0b3233593</originalsourceid><addsrcrecordid>eNqFkMtKAzEUhoMotla3LmXAjQun5jKXZFlbb1DoRt2GTJKhKXOpyUxldj6Cz-iTmKG1ghtX5_DznZ_DB8A5gmMEIb6RmdqMMcQRRATCAzBECcIhohQe7vcUD8CJcyvP-5wegwFhmCCM8BAsJlVjMiEbbY0oAlGpoE8KbdyyFFWfTWRjNqbpgjoP0HX09fE5M8tO2XrdWaNMpYOZP94IT2l3Co5yUTh9tpsj8HJ_9zx9DOeLh6fpZB5KHFMYUoh1njGmRY6oyqFiqUJZHCFKJKNpphOGSEIjQnXKIJQyirEkQsKMYEJiRkbgatu7tvVbq13DS-OkLgpR6bp1nHg7DEUxijx6-Qdd1a2t_HeeipOYkDSNPTXeUtLWzlmd87U1pbAdR5D3qnmvmu9V-4OLXW2blVrt8R-3HmBb4N3r7P6p49Pb2etv-TeQjonh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3156533775</pqid></control><display><type>article</type><title>Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Oliveira, Thaís A. S. ; Silva, Jackson B. A. ; Silva, Nagela B. S. ; Félix, Paulo C. A. ; Santos, Daiane A. ; Oliveira, Andreia M. ; Martins, Carlos H. G. ; Magalhães, Lizandra G. ; Crotti, Antônio E. M.</creator><creatorcontrib>Oliveira, Thaís A. S. ; Silva, Jackson B. A. ; Silva, Nagela B. S. ; Félix, Paulo C. A. ; Santos, Daiane A. ; Oliveira, Andreia M. ; Martins, Carlos H. G. ; Magalhães, Lizandra G. ; Crotti, Antônio E. M.</creatorcontrib><description>We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leishmania (L.) amazonensis promastigotes and amastigotes. Thirteen compounds were moderately active against Streptococcus sanguinis, Streptococcus mitis, and Lactobacillus paracasei. Compound 22 (diethyl 4‐(3‐methoxy‐4‐hydroxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate) displayed moderate antibacterial activity against S. mitis and S. sanguinis, with a Minimum Inhibitory Concentration (MIC) of 500 μg/mL); compounds 8 (ethyl 2,7,7‐trimethyl‐4‐(3‐chlorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 10 (ethyl 2,7,7‐trimethyl‐4‐(3‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were moderately active against S. sanguinis (MIC=500 μg/mL) and very active against L. amazonensis promastigotes (IC50=43.08 and 34.29 μM, respectively). Among the eight 1,4‐DHPs that were active (IC50 <50 μM) against L. amazonensis promastigotes, compound 13 (ethyl 2,7,7‐trimethyl‐4‐(3,4,5‐trimethoxyphenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) was the most active (IC50=24.62 μM) and had a Selectivity Index (SI) higher than 4 compared to GM07492 A cells. On the other hand, compounds 7 (ethyl 2,7,7‐trimethyl‐4‐(3‐fluorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 9 (ethyl 2,7,7‐trimethyl‐4‐(2‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were the most active against L. amazonensis amastigotes (IC50=12.53 and 13.67 μM, respectively; SI>7.9 and >7.3, respectively) after 24 h of treatment. Our results indicated that asymmetric 1,4‐DHPs derived from dimedone exhibit antileishmanial potential.</description><identifier>ISSN: 1612-1872</identifier><identifier>ISSN: 1612-1880</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202401300</identifier><identifier>PMID: 39231212</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>1,4-diidropyridine ; Amastigotes ; Animals ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antiinfectives and antibacterials ; Antiprotozoal Agents - chemical synthesis ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - pharmacology ; Bacteria ; Dihydropyridine ; Dihydropyridines - chemical synthesis ; Dihydropyridines - chemistry ; Dihydropyridines - pharmacology ; Dose-Response Relationship, Drug ; Leishmania - drug effects ; Leishmania amazonensis ; Mice ; Microbial Sensitivity Tests ; Microwave irradiation ; Minimum inhibitory concentration ; Molecular Structure ; Oral pathogens ; Parasitic Sensitivity Tests ; Promastigotes ; Streptococcus - drug effects ; Streptococcus mutans ; Structure-Activity Relationship</subject><ispartof>Chemistry & biodiversity, 2025-01, Vol.22 (1), p.e202401300-n/a</ispartof><rights>2024 Wiley-VHCA AG, Zurich, Switzerland</rights><rights>2024 Wiley-VHCA AG, Zurich, Switzerland.</rights><rights>2025 Wiley-VHCA AG, Zurich, Switzerland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2580-802efb99eaf18df0d97d1b54183c987be691368438e7900cc452c3ac0b3233593</cites><orcidid>0000-0002-1730-1729</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202401300$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202401300$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39231212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Thaís A. S.</creatorcontrib><creatorcontrib>Silva, Jackson B. A.</creatorcontrib><creatorcontrib>Silva, Nagela B. S.</creatorcontrib><creatorcontrib>Félix, Paulo C. A.</creatorcontrib><creatorcontrib>Santos, Daiane A.</creatorcontrib><creatorcontrib>Oliveira, Andreia M.</creatorcontrib><creatorcontrib>Martins, Carlos H. G.</creatorcontrib><creatorcontrib>Magalhães, Lizandra G.</creatorcontrib><creatorcontrib>Crotti, Antônio E. M.</creatorcontrib><title>Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leishmania (L.) amazonensis promastigotes and amastigotes. Thirteen compounds were moderately active against Streptococcus sanguinis, Streptococcus mitis, and Lactobacillus paracasei. Compound 22 (diethyl 4‐(3‐methoxy‐4‐hydroxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate) displayed moderate antibacterial activity against S. mitis and S. sanguinis, with a Minimum Inhibitory Concentration (MIC) of 500 μg/mL); compounds 8 (ethyl 2,7,7‐trimethyl‐4‐(3‐chlorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 10 (ethyl 2,7,7‐trimethyl‐4‐(3‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were moderately active against S. sanguinis (MIC=500 μg/mL) and very active against L. amazonensis promastigotes (IC50=43.08 and 34.29 μM, respectively). Among the eight 1,4‐DHPs that were active (IC50 <50 μM) against L. amazonensis promastigotes, compound 13 (ethyl 2,7,7‐trimethyl‐4‐(3,4,5‐trimethoxyphenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) was the most active (IC50=24.62 μM) and had a Selectivity Index (SI) higher than 4 compared to GM07492 A cells. On the other hand, compounds 7 (ethyl 2,7,7‐trimethyl‐4‐(3‐fluorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 9 (ethyl 2,7,7‐trimethyl‐4‐(2‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were the most active against L. amazonensis amastigotes (IC50=12.53 and 13.67 μM, respectively; SI>7.9 and >7.3, respectively) after 24 h of treatment. Our results indicated that asymmetric 1,4‐DHPs derived from dimedone exhibit antileishmanial potential.</description><subject>1,4-diidropyridine</subject><subject>Amastigotes</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antiinfectives and antibacterials</subject><subject>Antiprotozoal Agents - chemical synthesis</subject><subject>Antiprotozoal Agents - chemistry</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Bacteria</subject><subject>Dihydropyridine</subject><subject>Dihydropyridines - chemical synthesis</subject><subject>Dihydropyridines - chemistry</subject><subject>Dihydropyridines - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Leishmania - drug effects</subject><subject>Leishmania amazonensis</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Microwave irradiation</subject><subject>Minimum inhibitory concentration</subject><subject>Molecular Structure</subject><subject>Oral pathogens</subject><subject>Parasitic Sensitivity Tests</subject><subject>Promastigotes</subject><subject>Streptococcus - drug effects</subject><subject>Streptococcus mutans</subject><subject>Structure-Activity Relationship</subject><issn>1612-1872</issn><issn>1612-1880</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotla3LmXAjQun5jKXZFlbb1DoRt2GTJKhKXOpyUxldj6Cz-iTmKG1ghtX5_DznZ_DB8A5gmMEIb6RmdqMMcQRRATCAzBECcIhohQe7vcUD8CJcyvP-5wegwFhmCCM8BAsJlVjMiEbbY0oAlGpoE8KbdyyFFWfTWRjNqbpgjoP0HX09fE5M8tO2XrdWaNMpYOZP94IT2l3Co5yUTh9tpsj8HJ_9zx9DOeLh6fpZB5KHFMYUoh1njGmRY6oyqFiqUJZHCFKJKNpphOGSEIjQnXKIJQyirEkQsKMYEJiRkbgatu7tvVbq13DS-OkLgpR6bp1nHg7DEUxijx6-Qdd1a2t_HeeipOYkDSNPTXeUtLWzlmd87U1pbAdR5D3qnmvmu9V-4OLXW2blVrt8R-3HmBb4N3r7P6p49Pb2etv-TeQjonh</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Oliveira, Thaís A. S.</creator><creator>Silva, Jackson B. A.</creator><creator>Silva, Nagela B. S.</creator><creator>Félix, Paulo C. A.</creator><creator>Santos, Daiane A.</creator><creator>Oliveira, Andreia M.</creator><creator>Martins, Carlos H. G.</creator><creator>Magalhães, Lizandra G.</creator><creator>Crotti, Antônio E. M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1730-1729</orcidid></search><sort><creationdate>202501</creationdate><title>Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives</title><author>Oliveira, Thaís A. S. ; Silva, Jackson B. A. ; Silva, Nagela B. S. ; Félix, Paulo C. A. ; Santos, Daiane A. ; Oliveira, Andreia M. ; Martins, Carlos H. G. ; Magalhães, Lizandra G. ; Crotti, Antônio E. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2580-802efb99eaf18df0d97d1b54183c987be691368438e7900cc452c3ac0b3233593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>1,4-diidropyridine</topic><topic>Amastigotes</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antiinfectives and antibacterials</topic><topic>Antiprotozoal Agents - chemical synthesis</topic><topic>Antiprotozoal Agents - chemistry</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Bacteria</topic><topic>Dihydropyridine</topic><topic>Dihydropyridines - chemical synthesis</topic><topic>Dihydropyridines - chemistry</topic><topic>Dihydropyridines - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Leishmania - drug effects</topic><topic>Leishmania amazonensis</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Microwave irradiation</topic><topic>Minimum inhibitory concentration</topic><topic>Molecular Structure</topic><topic>Oral pathogens</topic><topic>Parasitic Sensitivity Tests</topic><topic>Promastigotes</topic><topic>Streptococcus - drug effects</topic><topic>Streptococcus mutans</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Thaís A. S.</creatorcontrib><creatorcontrib>Silva, Jackson B. A.</creatorcontrib><creatorcontrib>Silva, Nagela B. S.</creatorcontrib><creatorcontrib>Félix, Paulo C. A.</creatorcontrib><creatorcontrib>Santos, Daiane A.</creatorcontrib><creatorcontrib>Oliveira, Andreia M.</creatorcontrib><creatorcontrib>Martins, Carlos H. G.</creatorcontrib><creatorcontrib>Magalhães, Lizandra G.</creatorcontrib><creatorcontrib>Crotti, Antônio E. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Thaís A. S.</au><au>Silva, Jackson B. A.</au><au>Silva, Nagela B. S.</au><au>Félix, Paulo C. A.</au><au>Santos, Daiane A.</au><au>Oliveira, Andreia M.</au><au>Martins, Carlos H. G.</au><au>Magalhães, Lizandra G.</au><au>Crotti, Antônio E. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2025-01</date><risdate>2025</risdate><volume>22</volume><issue>1</issue><spage>e202401300</spage><epage>n/a</epage><pages>e202401300-n/a</pages><issn>1612-1872</issn><issn>1612-1880</issn><eissn>1612-1880</eissn><abstract>We have synthesized twenty‐three 1,4‐dihydropyridine derivatives (1,4‐DHPs) by using a microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leishmania (L.) amazonensis promastigotes and amastigotes. Thirteen compounds were moderately active against Streptococcus sanguinis, Streptococcus mitis, and Lactobacillus paracasei. Compound 22 (diethyl 4‐(3‐methoxy‐4‐hydroxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate) displayed moderate antibacterial activity against S. mitis and S. sanguinis, with a Minimum Inhibitory Concentration (MIC) of 500 μg/mL); compounds 8 (ethyl 2,7,7‐trimethyl‐4‐(3‐chlorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 10 (ethyl 2,7,7‐trimethyl‐4‐(3‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were moderately active against S. sanguinis (MIC=500 μg/mL) and very active against L. amazonensis promastigotes (IC50=43.08 and 34.29 μM, respectively). Among the eight 1,4‐DHPs that were active (IC50 <50 μM) against L. amazonensis promastigotes, compound 13 (ethyl 2,7,7‐trimethyl‐4‐(3,4,5‐trimethoxyphenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) was the most active (IC50=24.62 μM) and had a Selectivity Index (SI) higher than 4 compared to GM07492 A cells. On the other hand, compounds 7 (ethyl 2,7,7‐trimethyl‐4‐(3‐fluorophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) and 9 (ethyl 2,7,7‐trimethyl‐4‐(2‐nitrophenyl)‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate) were the most active against L. amazonensis amastigotes (IC50=12.53 and 13.67 μM, respectively; SI>7.9 and >7.3, respectively) after 24 h of treatment. Our results indicated that asymmetric 1,4‐DHPs derived from dimedone exhibit antileishmanial potential.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39231212</pmid><doi>10.1002/cbdv.202401300</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1730-1729</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1612-1872 |
| ispartof | Chemistry & biodiversity, 2025-01, Vol.22 (1), p.e202401300-n/a |
| issn | 1612-1872 1612-1880 1612-1880 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3100914514 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 1,4-diidropyridine Amastigotes Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antiinfectives and antibacterials Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Bacteria Dihydropyridine Dihydropyridines - chemical synthesis Dihydropyridines - chemistry Dihydropyridines - pharmacology Dose-Response Relationship, Drug Leishmania - drug effects Leishmania amazonensis Mice Microbial Sensitivity Tests Microwave irradiation Minimum inhibitory concentration Molecular Structure Oral pathogens Parasitic Sensitivity Tests Promastigotes Streptococcus - drug effects Streptococcus mutans Structure-Activity Relationship |
| title | Antibacterial and Antileishmanial Activity of 1,4‐Dihydropyridine Derivatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A09%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibacterial%20and%20Antileishmanial%20Activity%20of%201,4%E2%80%90Dihydropyridine%20Derivatives&rft.jtitle=Chemistry%20&%20biodiversity&rft.au=Oliveira,%20Tha%C3%ADs%20A.%20S.&rft.date=2025-01&rft.volume=22&rft.issue=1&rft.spage=e202401300&rft.epage=n/a&rft.pages=e202401300-n/a&rft.issn=1612-1872&rft.eissn=1612-1880&rft_id=info:doi/10.1002/cbdv.202401300&rft_dat=%3Cproquest_cross%3E3100914514%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3156533775&rft_id=info:pmid/39231212&rfr_iscdi=true |