Insights into the Role of Side-Chain Team Work in nDsbDOx/Red Proteins: Mechanism of Substrate Binding

N-terminal disulfide bond oxidoreductase (nDsbDOx/Red) proteins display divergent substrate binding mechanisms depending on the conformational changes to the Phe70 cap, which is also dependent on the disulfide redox state. In nDsbDOx, the cap dynamics is complex (shows both open/closed Phe70 cap con...

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Veröffentlicht in:	The journal of physical chemistry. B 2024-10, Vol.128 (43), p.10541-10552
Hauptverfasser:	Nair, Aparna G., Anjukandi, Padmesh
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites B: Biophysical and Biochemical Systems and Processes dissociation disulfide bonds disulfides electron transfer Lewis bases molecular dynamics teams
Online-Zugang:	Volltext
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