Oral Patch/Film for Drug Delivery—Current Status and Future Prospects
ABSTRACT In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to by...
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| Veröffentlicht in: | Biopolymers 2024-11, Vol.115 (6), p.e23625-n/a |
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| container_title | Biopolymers |
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| creator | Yan, Yujie Yan, Wenjie Wu, Sihua Zhao, Hang Chen, Qianming Wang, Jiongke |
| description | ABSTRACT
In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first‐pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems. |
| doi_str_mv | 10.1002/bip.23625 |
| format | Article |
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In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first‐pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems.</description><identifier>ISSN: 0006-3525</identifier><identifier>ISSN: 1097-0282</identifier><identifier>EISSN: 1097-0282</identifier><identifier>DOI: 10.1002/bip.23625</identifier><identifier>PMID: 39230032</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Administration, Oral ; Bioavailability ; biocompatible materials ; Biological Availability ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug development ; Drug metabolism ; Humans ; Mouth - metabolism ; Oral administration ; Oral cavity ; patient comfort ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - chemistry ; tissue adhesives ; topical administrations</subject><ispartof>Biopolymers, 2024-11, Vol.115 (6), p.e23625-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2435-7b9e07613e259abebb71e3a895309a757915f83b89f9cf2764be95e01f6dcc493</cites><orcidid>0000-0001-6455-1926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbip.23625$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbip.23625$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39230032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Yujie</creatorcontrib><creatorcontrib>Yan, Wenjie</creatorcontrib><creatorcontrib>Wu, Sihua</creatorcontrib><creatorcontrib>Zhao, Hang</creatorcontrib><creatorcontrib>Chen, Qianming</creatorcontrib><creatorcontrib>Wang, Jiongke</creatorcontrib><title>Oral Patch/Film for Drug Delivery—Current Status and Future Prospects</title><title>Biopolymers</title><addtitle>Biopolymers</addtitle><description>ABSTRACT
In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first‐pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems.</description><subject>Administration, Oral</subject><subject>Bioavailability</subject><subject>biocompatible materials</subject><subject>Biological Availability</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug development</subject><subject>Drug metabolism</subject><subject>Humans</subject><subject>Mouth - metabolism</subject><subject>Oral administration</subject><subject>Oral cavity</subject><subject>patient comfort</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>tissue adhesives</subject><subject>topical administrations</subject><issn>0006-3525</issn><issn>1097-0282</issn><issn>1097-0282</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10L1OwzAUBWALgWgpDLwAisQCQ9prO07qEVpaKlVqJWCOnPQGUuWn2DGoGw_BE_IkGFIYkJju8uno3EPIKYU-BWCDJN_0GQ-Z2CNdCjLygQ3ZPukCQOhzwUSHHBmzBggCTuGQdLhkHICzLpkutCq8pWrSp8EkL0ovq7U31vbRG2ORv6Defry9j6zWWDXeXaMaazxVrbyJbaxGb6lrs8G0McfkIFOFwZPd7ZGHyc396NafL6az0dXcT1nAhR8lEiEKKUcmpEowSSKKXA2l4CBVJCJJRTbkyVBmMs1YFAYJSoFAs3CVpoHkPXLR5m50_WzRNHGZmxSLQlVYWxO7_0CEQRiFjp7_oeva6sq1c8o5xrnr1COXrUrdK0ZjFm90Xiq9jSnEX-vGbt34e11nz3aJNilx9St_5nRg0ILXvMDt_0nx9WzZRn4CILKCRg</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Yan, Yujie</creator><creator>Yan, Wenjie</creator><creator>Wu, Sihua</creator><creator>Zhao, Hang</creator><creator>Chen, Qianming</creator><creator>Wang, Jiongke</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6455-1926</orcidid></search><sort><creationdate>202411</creationdate><title>Oral Patch/Film for Drug Delivery—Current Status and Future Prospects</title><author>Yan, Yujie ; Yan, Wenjie ; Wu, Sihua ; Zhao, Hang ; Chen, Qianming ; Wang, Jiongke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2435-7b9e07613e259abebb71e3a895309a757915f83b89f9cf2764be95e01f6dcc493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Oral</topic><topic>Bioavailability</topic><topic>biocompatible materials</topic><topic>Biological Availability</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug development</topic><topic>Drug metabolism</topic><topic>Humans</topic><topic>Mouth - metabolism</topic><topic>Oral administration</topic><topic>Oral cavity</topic><topic>patient comfort</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>tissue adhesives</topic><topic>topical administrations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Yujie</creatorcontrib><creatorcontrib>Yan, Wenjie</creatorcontrib><creatorcontrib>Wu, Sihua</creatorcontrib><creatorcontrib>Zhao, Hang</creatorcontrib><creatorcontrib>Chen, Qianming</creatorcontrib><creatorcontrib>Wang, Jiongke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biopolymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Yujie</au><au>Yan, Wenjie</au><au>Wu, Sihua</au><au>Zhao, Hang</au><au>Chen, Qianming</au><au>Wang, Jiongke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Patch/Film for Drug Delivery—Current Status and Future Prospects</atitle><jtitle>Biopolymers</jtitle><addtitle>Biopolymers</addtitle><date>2024-11</date><risdate>2024</risdate><volume>115</volume><issue>6</issue><spage>e23625</spage><epage>n/a</epage><pages>e23625-n/a</pages><issn>0006-3525</issn><issn>1097-0282</issn><eissn>1097-0282</eissn><abstract>ABSTRACT
In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first‐pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>39230032</pmid><doi>10.1002/bip.23625</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-6455-1926</orcidid></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Administration, Oral Bioavailability biocompatible materials Biological Availability Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug development Drug metabolism Humans Mouth - metabolism Oral administration Oral cavity patient comfort Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry tissue adhesives topical administrations |
| title | Oral Patch/Film for Drug Delivery—Current Status and Future Prospects |
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