Exosomal Non-coding RNA Derived from Mesenchymal Stem Cells (MSCs) in Autoimmune Diseases Progression and Therapy; an Updated Review
Inflammation and autoimmune diseases (AD) are common outcomes of an overactive immune system. Inflammation occurs due to the immune system reacting to damaging stimuli. Exosomes are being recognized as an advanced therapeutic approach for addressing an overactive immune system, positioning them as a...
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| Veröffentlicht in: | Cell biochemistry and biophysics 2024-12, Vol.82 (4), p.3091-3108 |
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| creator | Farhan, Shireen Hamid Jasim, Saade Abdalkareem Bansal, Pooja Kaur, Harpreet Abed Jawad, Mohammed Qasim, Maytham T. Jabbar, Abeer Mhussan Deorari, Mahamedha Alawadi, Ahmed Hadi, Ali |
| description | Inflammation and autoimmune diseases (AD) are common outcomes of an overactive immune system. Inflammation occurs due to the immune system reacting to damaging stimuli. Exosomes are being recognized as an advanced therapeutic approach for addressing an overactive immune system, positioning them as a promising option for treating AD. Mesenchymal stem cells (MSCs) release exosomes that have strong immunomodulatory effects, influenced by their cell of origin. MSCs-exosomes, being a cell-free therapy, exhibit less toxicity and provoke a diminished immune response compared to cell-based therapies. Exosomal non-coding RNAs (ncRNA), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are intricately linked to various biological and functional aspects of human health. Exosomal ncRNAs can lead to tissue malfunction, aging, and illnesses when they experience tissue-specific alterations as a result of various internal or external problems. In this study, we will examine current trends in exosomal ncRNA researches regarding AD. Then, therapeutic uses of MSCs-exosomal ncRNA will be outlined, with a particle focus on the underlying molecular mechanisms. |
| doi_str_mv | 10.1007/s12013-024-01432-4 |
| format | Article |
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| subjects | Animals Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoimmune Diseases - therapy Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Exosomes Exosomes - metabolism Humans Immune response Immune system Immunomodulation Inflammation Life Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - therapeutic use miRNA Molecular modelling Non-coding RNA Pharmacology/Toxicology Review Paper RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Long Noncoding - therapeutic use Stem cells Toxicity |
| title | Exosomal Non-coding RNA Derived from Mesenchymal Stem Cells (MSCs) in Autoimmune Diseases Progression and Therapy; an Updated Review |
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