Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures

Current medical countermeasures (MCMs) for nerve agent poisoning have limited efficacy, and can cause serious adverse effects, prompting the requirement for new broad-spectrum therapeutics. Human plasma-derived butyrylcholinseterase (huBChE) is a promising novel bioscavenger MCM which has shown pote...

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Veröffentlicht in:	Chemico-biological interactions 2024-11, Vol.403, p.111219, Article 111219
Hauptverfasser:	Allard, Joanne L., Aguirre, Miguel, Gupta, Ruchi, Chua, Sheena.M.H., Shields, Katherine A., Lua, Linda.H.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioscavenger Butyrylcholinesterase Medical countermeasure Nerve agents Organophosphates Recombinant protein
Online-Zugang:	Volltext
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