Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation
To evaluate the efficacy of yellow light-emitting diode (LED) irradiation at 590 nm, alone or in combination with anti-inflammatory active substances against ultraviolet (UV)-induced inflammation in keratinocytes. HaCaT keratinocytes were pretreated with LED yellow light (590 nm) alone or in combina...
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| Veröffentlicht in: | Lasers in medical science 2024-09, Vol.39 (1), p.231, Article 231 |
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| creator | Qin, Yumei Jiang, Boyang Yuan, Chunfen Cui, Lei Lu, Ming Zheng, Xia Yu, Minmin |
| description | To evaluate the efficacy of yellow light-emitting diode (LED) irradiation at 590 nm, alone or in combination with anti-inflammatory active substances against ultraviolet (UV)-induced inflammation in keratinocytes. HaCaT keratinocytes were pretreated with LED yellow light (590 nm) alone or in combination with an antiinflammatory active substance such as glycerophosphoinositol choline (GC), extract of grains of paradise (Aframomum melegueta Schum, AM), or a bisabolol and ginger root extract mixture (Bb-GE) before UVB irradiation. Following each treatment, we measured the levels of inflammatory mediators secreted by keratinocytes. HaCaT keratinocytes treated with UVB (300 mJ cm
−
²) and then cultured for 24 h exhibited significantly upregulated expression of proinflammatory factors, including interleukin (IL)-1α, prostaglandin E2 (PGE2), and IL-8. After pretreatment with 590 nm LED, UVB-induced inflammatory responses were significantly inhibited. Co-pretreatment with 590 nm LED irradiation and GC further inhibited the expression of IL-1α and IL-8. IL-8 expression was inhibited by co-pretreatment with 590 nm LED irradiation and AM, whereas PGE2 expression was inhibited by co-pretreatment with 590 nm LED irradiation and Bb-GE. Co-treatment with 590 nm LED irradiation and various active substances modulated UVB-induced inflammation in keratinocytes, suggesting the potential application of this approach to prevent damage caused by voluntary sun exposure in daily life. |
| doi_str_mv | 10.1007/s10103-024-04178-w |
| format | Article |
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−
²) and then cultured for 24 h exhibited significantly upregulated expression of proinflammatory factors, including interleukin (IL)-1α, prostaglandin E2 (PGE2), and IL-8. After pretreatment with 590 nm LED, UVB-induced inflammatory responses were significantly inhibited. Co-pretreatment with 590 nm LED irradiation and GC further inhibited the expression of IL-1α and IL-8. IL-8 expression was inhibited by co-pretreatment with 590 nm LED irradiation and AM, whereas PGE2 expression was inhibited by co-pretreatment with 590 nm LED irradiation and Bb-GE. Co-treatment with 590 nm LED irradiation and various active substances modulated UVB-induced inflammation in keratinocytes, suggesting the potential application of this approach to prevent damage caused by voluntary sun exposure in daily life.</description><identifier>ISSN: 1435-604X</identifier><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-024-04178-w</identifier><identifier>PMID: 39223344</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Choline ; Damage prevention ; Dentistry ; Dinoprostone - metabolism ; Glycerophosphoinositol ; HaCaT Cells ; Humans ; Inflammation ; Interleukin 8 ; Interleukin-1alpha - metabolism ; Interleukin-8 - metabolism ; Irradiation ; Keratinocytes ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; Keratinocytes - radiation effects ; Lasers ; Lasers, Semiconductor - therapeutic use ; Light emitting diodes ; Medicine ; Medicine & Public Health ; Monocyclic Sesquiterpenes - pharmacology ; Optical Devices ; Optics ; Original Article ; Photonics ; Plant Extracts - pharmacology ; Pretreatment ; Prostaglandin E2 ; Quantum Optics ; Radiation damage ; Radiation effects ; Sesquiterpenes - pharmacology ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects</subject><ispartof>Lasers in medical science, 2024-09, Vol.39 (1), p.231, Article 231</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-3a2418ef4539bc00a9fa8e8fe59557a2f4829bd024926bf8935a3edd333687a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-024-04178-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-024-04178-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39223344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Yumei</creatorcontrib><creatorcontrib>Jiang, Boyang</creatorcontrib><creatorcontrib>Yuan, Chunfen</creatorcontrib><creatorcontrib>Cui, Lei</creatorcontrib><creatorcontrib>Lu, Ming</creatorcontrib><creatorcontrib>Zheng, Xia</creatorcontrib><creatorcontrib>Yu, Minmin</creatorcontrib><title>Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>To evaluate the efficacy of yellow light-emitting diode (LED) irradiation at 590 nm, alone or in combination with anti-inflammatory active substances against ultraviolet (UV)-induced inflammation in keratinocytes. HaCaT keratinocytes were pretreated with LED yellow light (590 nm) alone or in combination with an antiinflammatory active substance such as glycerophosphoinositol choline (GC), extract of grains of paradise (Aframomum melegueta Schum, AM), or a bisabolol and ginger root extract mixture (Bb-GE) before UVB irradiation. Following each treatment, we measured the levels of inflammatory mediators secreted by keratinocytes. HaCaT keratinocytes treated with UVB (300 mJ cm
−
²) and then cultured for 24 h exhibited significantly upregulated expression of proinflammatory factors, including interleukin (IL)-1α, prostaglandin E2 (PGE2), and IL-8. After pretreatment with 590 nm LED, UVB-induced inflammatory responses were significantly inhibited. Co-pretreatment with 590 nm LED irradiation and GC further inhibited the expression of IL-1α and IL-8. IL-8 expression was inhibited by co-pretreatment with 590 nm LED irradiation and AM, whereas PGE2 expression was inhibited by co-pretreatment with 590 nm LED irradiation and Bb-GE. Co-treatment with 590 nm LED irradiation and various active substances modulated UVB-induced inflammation in keratinocytes, suggesting the potential application of this approach to prevent damage caused by voluntary sun exposure in daily life.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Choline</subject><subject>Damage prevention</subject><subject>Dentistry</subject><subject>Dinoprostone - metabolism</subject><subject>Glycerophosphoinositol</subject><subject>HaCaT Cells</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 8</subject><subject>Interleukin-1alpha - metabolism</subject><subject>Interleukin-8 - metabolism</subject><subject>Irradiation</subject><subject>Keratinocytes</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - radiation effects</subject><subject>Lasers</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Light emitting diodes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monocyclic Sesquiterpenes - pharmacology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Plant Extracts - pharmacology</subject><subject>Pretreatment</subject><subject>Prostaglandin E2</subject><subject>Quantum Optics</subject><subject>Radiation damage</subject><subject>Radiation effects</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>1435-604X</issn><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9uFTEMxkcIREvhAixQJDZsQpM4mZksoeKf9KRuisQuyiSZ15RJUpJMn3oKrsBZOBmhrxTEoitb9s-fLX9d95yS15SQ4bhQQglgwjgmnA4j3j3oDikHgXvCvzz8Jz_onpRyQQgdegqPuwOQjAFwfth93_jtecUu-Fp93CLrk3XI56yt19WniHRFQpKfP2JAJoXJR2fRztdzpE31Vw6VdSpVR-MKCsmui64tW5ea9ZVPi6voLboTwz7a1TSBry63QkzmurZtcV50CDfE0-7RrJfint3Go-7z-3dnJx_x5vTDp5M3G2yY6CsGzTgd3cwFyMkQouWsRzfOTkghBs1mPjI52fYayfppHiUIDc5aAOjHQQs46l7tdS9z-ra6UlXwxbhl0dGltShoH2YDcEob-vI_9CKtObbrFBApJRkBSKPYnjI5lZLdrC6zDzpfK0rUb7vU3i7VblI3dqldG3pxK71Owdm7kT_-NAD2QGmtuHX57-57ZH8BtW6j2Q</recordid><startdate>20240903</startdate><enddate>20240903</enddate><creator>Qin, Yumei</creator><creator>Jiang, Boyang</creator><creator>Yuan, Chunfen</creator><creator>Cui, Lei</creator><creator>Lu, Ming</creator><creator>Zheng, Xia</creator><creator>Yu, Minmin</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>H8D</scope><scope>K9.</scope><scope>L7M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240903</creationdate><title>Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation</title><author>Qin, Yumei ; Jiang, Boyang ; Yuan, Chunfen ; Cui, Lei ; Lu, Ming ; Zheng, Xia ; Yu, Minmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-3a2418ef4539bc00a9fa8e8fe59557a2f4829bd024926bf8935a3edd333687a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Choline</topic><topic>Damage prevention</topic><topic>Dentistry</topic><topic>Dinoprostone - metabolism</topic><topic>Glycerophosphoinositol</topic><topic>HaCaT Cells</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 8</topic><topic>Interleukin-1alpha - metabolism</topic><topic>Interleukin-8 - metabolism</topic><topic>Irradiation</topic><topic>Keratinocytes</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - metabolism</topic><topic>Keratinocytes - radiation effects</topic><topic>Lasers</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Light emitting diodes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monocyclic Sesquiterpenes - pharmacology</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Photonics</topic><topic>Plant Extracts - pharmacology</topic><topic>Pretreatment</topic><topic>Prostaglandin E2</topic><topic>Quantum Optics</topic><topic>Radiation damage</topic><topic>Radiation effects</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qin, Yumei</creatorcontrib><creatorcontrib>Jiang, Boyang</creatorcontrib><creatorcontrib>Yuan, Chunfen</creatorcontrib><creatorcontrib>Cui, Lei</creatorcontrib><creatorcontrib>Lu, Ming</creatorcontrib><creatorcontrib>Zheng, Xia</creatorcontrib><creatorcontrib>Yu, Minmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Yumei</au><au>Jiang, Boyang</au><au>Yuan, Chunfen</au><au>Cui, Lei</au><au>Lu, Ming</au><au>Zheng, Xia</au><au>Yu, Minmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2024-09-03</date><risdate>2024</risdate><volume>39</volume><issue>1</issue><spage>231</spage><pages>231-</pages><artnum>231</artnum><issn>1435-604X</issn><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>To evaluate the efficacy of yellow light-emitting diode (LED) irradiation at 590 nm, alone or in combination with anti-inflammatory active substances against ultraviolet (UV)-induced inflammation in keratinocytes. HaCaT keratinocytes were pretreated with LED yellow light (590 nm) alone or in combination with an antiinflammatory active substance such as glycerophosphoinositol choline (GC), extract of grains of paradise (Aframomum melegueta Schum, AM), or a bisabolol and ginger root extract mixture (Bb-GE) before UVB irradiation. Following each treatment, we measured the levels of inflammatory mediators secreted by keratinocytes. HaCaT keratinocytes treated with UVB (300 mJ cm
−
²) and then cultured for 24 h exhibited significantly upregulated expression of proinflammatory factors, including interleukin (IL)-1α, prostaglandin E2 (PGE2), and IL-8. After pretreatment with 590 nm LED, UVB-induced inflammatory responses were significantly inhibited. Co-pretreatment with 590 nm LED irradiation and GC further inhibited the expression of IL-1α and IL-8. IL-8 expression was inhibited by co-pretreatment with 590 nm LED irradiation and AM, whereas PGE2 expression was inhibited by co-pretreatment with 590 nm LED irradiation and Bb-GE. Co-treatment with 590 nm LED irradiation and various active substances modulated UVB-induced inflammation in keratinocytes, suggesting the potential application of this approach to prevent damage caused by voluntary sun exposure in daily life.</abstract><cop>London</cop><pub>Springer London</pub><pmid>39223344</pmid><doi>10.1007/s10103-024-04178-w</doi></addata></record> |
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| subjects | Anti-Inflammatory Agents - pharmacology Choline Damage prevention Dentistry Dinoprostone - metabolism Glycerophosphoinositol HaCaT Cells Humans Inflammation Interleukin 8 Interleukin-1alpha - metabolism Interleukin-8 - metabolism Irradiation Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Lasers Lasers, Semiconductor - therapeutic use Light emitting diodes Medicine Medicine & Public Health Monocyclic Sesquiterpenes - pharmacology Optical Devices Optics Original Article Photonics Plant Extracts - pharmacology Pretreatment Prostaglandin E2 Quantum Optics Radiation damage Radiation effects Sesquiterpenes - pharmacology Ultraviolet radiation Ultraviolet Rays - adverse effects |
| title | Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation |
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