Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production

Long-term hyperuricemia can induce kidney damage, clinically referred to as hyperuricemic nephropathy (HN), which is characterized by renal fibrosis, inflammation, and oxidative stress. However, currently used uric acid-lowering drugs are not capable of protecting the kidneys from damage. Therefore,...

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Veröffentlicht in:Chemico-biological interactions 2024-11, Vol.403, p.111220, Article 111220
Hauptverfasser: Chen, Yong-jun, Guo, Zi-tao, Chen, Hai-qiao, Zhang, Shi-fan, Bao, Ying-xia, Xie, Zhoufan, Ke, Jia-le, Ye, Wen-jie, Liang, Jia-cheng, Chen, Jia-chen, Li, Ning, Zheng, Feng-xin, Liao, Hui, Wu, Ting, Pang, Jian-xin
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Sprache:eng
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