Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

High-fat diet (HFD) currently is reported that in connection with cognitive impairment. Tirzepatide is a novel dual receptor agonist for glycemic control. But whether Tirzepatide exerts a protective effect in HFD-related cognitive impairment remains to be explore. During the study, the cognitive dys...

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Veröffentlicht in:Endocrine 2024-09
Hauptverfasser: Ma, Jingjing, Liu, Yuanyuan, Hu, Junya, Liu, Xingjing, Xia, Yin, Xia, Wenqing, Shen, Ziyang, Kong, Xiaocen, Wu, Xia, Mao, Li, Li, Qian
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container_title Endocrine
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creator Ma, Jingjing
Liu, Yuanyuan
Hu, Junya
Liu, Xingjing
Xia, Yin
Xia, Wenqing
Shen, Ziyang
Kong, Xiaocen
Wu, Xia
Mao, Li
Li, Qian
description High-fat diet (HFD) currently is reported that in connection with cognitive impairment. Tirzepatide is a novel dual receptor agonist for glycemic control. But whether Tirzepatide exerts a protective effect in HFD-related cognitive impairment remains to be explore. During the study, the cognitive dysfunction mice model induced by HFD were established. The expressions synapse-associated protein and other target proteins were detected. The oxidative stress parameters, levels of inflammatory cytokine were also detected. Our findings proved that Tirzepatide administration attenuates high fat diet-related cognitive impairment. Tirzepatide administration suppresses microglia activation, alleviates oxidative stress as well as suppressed the expression of NLRP3 in HFD mice by up-regulating SIRT3 expression. In conclusion, Tirzepatide attenuates HFD-induced cognitive impairment through reducing oxidative stress and neuroinflammation via SIRT3-NLRP3 signaling. This study suggest that Tirzepatide has neuroprotective effects in HFD-related cognitive dysfunction mice model, which provides a promising treatment of HFD-related cognitive impairment.
doi_str_mv 10.1007/s12020-024-04013-w
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title Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis
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