Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain

COVID-19 has caused millions of deaths and many times more infections worldwide, emphasizing the unpreparedness of the global health system in the face of new infections and the key role for vaccines and therapeutics, including virus-neutralizing antibodies, in prevention and containment of the dise...

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Veröffentlicht in:	Biochemistry (Moscow) 2024-07, Vol.89 (7), p.1260-1272
Hauptverfasser:	Sluchanko, Nikolai N., Shcheblyakov, Dmitry V., Varfolomeeva, Larisa A., Favorskaya, Irina A., Dolzhikova, Inna V., Korobkova, Anastasia I., Alekseeva, Irina A., Esmagambetov, Ilias B., Derkaev, Artem A., Prokofiev, Vladimir V., Zorkov, Ilya D., Logunov, Denis Y., Gintsburg, Alexander L., Popov, Vladimir O., Boyko, Konstantin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - chemistry Angiotensin-Converting Enzyme 2 - immunology Angiotensin-Converting Enzyme 2 - metabolism Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Binding Binding Sites Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Clinical trials Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - virology Crystal structure Epitope mapping Epitopes - chemistry Epitopes - immunology Global health Humans Immune Evasion Immune system Life Sciences Microbiology Models, Molecular Nanobodies Neutralization Neutralizing Protein Binding Protein Domains Proteins Public health Receptors SARS-CoV-2 - drug effects SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Single-Domain Antibodies - chemistry Single-Domain Antibodies - immunology Single-Domain Antibodies - pharmacology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Vaccines Viral diseases Viruses
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