Reductions in functional muscle mass and ability to ambulate in Duchenne muscular dystrophy from ages 4 to 24 years

Duchenne muscular dystrophy (DMD) results in a progressive loss of functional skeletal muscle mass (MM) and replacement with fibrofatty tissue. Accurate evaluation of MM in DMD patients has not previously been available. Our objective was to measure MM using the D3creatine (D3Cr) dilution method and...

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Veröffentlicht in:	The Journal of physiology 2024-10, Vol.602 (19), p.4929-4939
Hauptverfasser:	Evans, William J., Hellerstein, Marc, Butterfield, Russell J., Smith, Edward, Guglieri, Michela, Katz, Natalie, Nave, Brittany, Branigan, Lauren, Thera, Stephanie, Vordos, Kalista L., Behar, Laura, Schiava, Marianela, James, Meredith K., Field, Tyler, Mohammed, Hussein, Shankaran, Mahalakshmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age ambulatory status Body weight D3creatine dilution Duchenne's muscular dystrophy functional capacity Liquid chromatography Mass spectroscopy muscle mass Muscular dystrophy Neuromuscular diseases Skeletal muscle
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