An unexpected degradation pathway of N-hydroxy-5-methylfuran-2-sulfonamide (BMS-986231), a pH sensitive prodrug of HNO, in a prototype formulation solution

•A metastable degradant of Cimlanod was isolated via LC-HRMS/MS guided synthesis.•Structure elucidation of the degradant was conducted via single crystal X-ray crystallography.•Plausible degradation pathways of Cimlanod in the prototype formulation solution under stressed conditions were proposed. N...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-11, Vol.113 (11), p.3315-3322
Hauptverfasser:	Huang, Yande, Sarjeant, Amy, Sommer, Roger, Patel, Dhaval, Wang, Qinggang, Bindra, Dilbir, Miller, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical - methods Chromatography, High Pressure Liquid - methods Degradation products Drug Stability Freeze Drying HNO Hydrogen-Ion Concentration Liquid-chromatography-high resolution mass spectrometry (LC-HRMS) Nitrogen Oxides Prodrugs - chemistry Single crystal X-ray crystallography Stability Sulfonamides - chemistry
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