Efficacy and safety of low‐dose digoxin in patients with heart failure. Rationale and design of the DECISION trial

Aims Digoxin is the oldest drug in cardiovascular (CV) medicine, and one trial conducted >25 years ago showed a reduction in heart failure (HF) hospitalizations but no effect on mortality. However, later studies suggested that the dose of digoxin used in that trial (and other studies) may have be...

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Veröffentlicht in:	European journal of heart failure 2024-10, Vol.26 (10), p.2223-2230
Hauptverfasser:	Veldhuisen, Dirk J., Rienstra, Michiel, Mosterd, Arend, Alings, A. Marco, Asselt, Antoinette D.J., Bouvy, Marcel L, Tijssen, Jan G.P., Schaap, Jeroen, Wall, Ernst E., Voors, Adriaan A., Boorsma, Eva M., Lok, Dirk J.A., Crijns, Harry J.G.M., Schut, Astrid, Vijver, Marlene A.T., Voordes, Geert H.D., Vos, Agaath H., Maas‐Soer, Ester L., Smit, Nicoline W., Touw, Daan J., Samuel, Michelle, Meer, Peter, Alings, Marco, Tijssen, Jan, Asselt, Thea, Bouvy, Marcel, Crijns, Harry J. G. M., Gaillard, Carlo, Veeger, Nick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiotonic Agents - administration & dosage Cardiotonic Agents - therapeutic use Digoxin Digoxin - administration & dosage Digoxin - adverse effects Digoxin - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Female Heart failure Heart Failure - drug therapy Heart Failure - mortality Heart Failure - physiopathology Hospitalization - statistics & numerical data Hospitalizations Humans Low‐dose Male Middle Aged Mortality Netherlands - epidemiology Randomized clinical trial Stroke Volume - physiology Treatment Outcome Ventricular Function, Left - drug effects Ventricular Function, Left - physiology
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