Advancements in platinum-based anticancer drug development: A comprehensive review of strategies, discoveries, and future perspectives

[Display omitted] •Platinum-based anticancer drugs induce apoptosis by forming platinum-DNA adducts.•These drugs exhibit significant efficacy in treating testicular, ovarian, colorectal, lung, and bladder cancers.•Resistance via enhanced DNA repair, drug efflux, and glutathione inactivation, causing...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2024-10, Vol.112, p.117894, Article 117894
Hauptverfasser:	Sahoo, Debsankar, Deb, Priya, Basu, Tamal, Bardhan, Srishti, Patra, Sayan, Sukul, Pradip K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer therapy Cisplatin Drug Development Humans Molecular Structure Neoplasms - drug therapy Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Photochemotherapy Platinum - chemistry Platinum complexes Prodrugs Prodrugs - chemistry Prodrugs - pharmacology Target specific anticancer
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