Cantharidin and sodium fluoride attenuate the negative inotropic effect of the A1-adenosine receptor agonist N6-(R)-phenylisopropyl adenosine in isolated human atria

Cantharidin and sodium fluoride inhibit the activity of serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A) and increase the force of contraction in human atrial preparations. R-phenylisopropyl adenosine (R-PIA) acts as an agonist at A 1 -adenosine receptors. R-PIA exerts a negative inotropi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-08, Vol.398 (2), p.1961-1971
Hauptverfasser:	Schwarz, R., Hofmann, B., Gergs, U., Neumann, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine A1 receptors Adenylate cyclase Agonists Biomedical and Life Sciences Biomedicine Fluorides Isometric Neurosciences Pharmacology/Toxicology Phosphatase Potassium channels Receptor mechanisms Serine Sodium fluoride Threonine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!