An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function

Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in the dentate gyrus, which has been postulated to be crucial for the development of psychotic associations and memories with psychotic content. Drugs modulating glycine levels are in clinical development for i...

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Veröffentlicht in:	Molecular psychiatry 2024-08
Hauptverfasser:	Kambali, Maltesh, Li, Yan, Unichenko, Petr, Feria Pliego, Jessica A, Yadav, Rachita, Liu, Jing, McGuinness, Patrick, Cobb, Johanna G, Wang, Muxiao, Nagarajan, Rajasekar, Lyu, Jinrui, Vongsouthi, Vanessa, Jackson, Colin J, Engin, Elif, Coyle, Joseph T, Shin, Jaeweon, Hodgson, Nathaniel W, Hensch, Takao K, Talkowski, Michael E, Homanics, Gregg E, Bolshakov, Vadim Y, Henneberger, Christian, Rudolph, Uwe
Format:	Artikel
Sprache:	eng
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