The complex non-genetic inheritance of complex traits

The complex non-genetic inheritance of complex traits

Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation.

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Veröffentlicht in:Nature reviews. Genetics 2024-10, Vol.25 (10), p.678-678
1. Verfasser: Vogt, Merly C.
Format: Artikel
Sprache:eng
Schlagworte:
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631/208/176
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Agriculture
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Gene Function
Heredity
Histone H3
Histones
Human Genetics
Humans
Journal Club
Methylation
Multifactorial Inheritance - genetics
Phenotype
Quantitative Trait, Heritable
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Beschreibung
Zusammenfassung:Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation.
ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-024-00770-6