Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-κB and MAPK signaling pathways

Excessive activity of osteoclasts(OCs) lead to bone resorption in chronic inflammatory conditions. The use of natural compounds to target OCs offers significant promise in the treatment or prevention of OC-associated diseases. Irilin D (IRD), a natural isoflavone derived from Belamcanda chinensis (L...

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Veröffentlicht in:	European journal of pharmacology 2024-11, Vol.982, p.176956, Article 176956
Hauptverfasser:	Gal, Minju, Tuan, Ha Manh, Park, Ju-Hee, Park, Kang-Hyeon, Kim, Okhwa, Min, Byung-Sun, Lee, Jeong-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Resorption - chemically induced Bone Resorption - drug therapy Bone Resorption - metabolism Bone Resorption - pathology Bone Resorption - prevention & control c-Fos Cell Differentiation - drug effects Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammatory bone loss Irilin D Isoflavone Isoflavones - pharmacology Isoflavones - therapeutic use Lipopolysaccharides Male MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL NF-kappa B - metabolism NFATC Transcription Factors - metabolism NFATc1 Osteoclastogenesis Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects RANK Ligand - metabolism RAW 264.7 Cells
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