Downregulation of MMP-9 by epicatechin can improve the radiosensitivity of non-small cell lung cancer

Radiation therapy is a crucial treatment for nonsmall cell lung cancer (NSCLC), but its effectiveness is limited by the resistance of tumor cells to radiation. This study aimed to evaluate the effect of epicatechin (EC) on radiosensitivity in NSCLC and to determine its relationships with matrix meta...

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Veröffentlicht in:	Journal of cancer research and therapeutics 2024-08, Vol.20 (4), p.1284-1292
Hauptverfasser:	Wu, Anao, He, Yongmei, Zhou, Huahua, Huang, Nan, Xu, Hongying, Xia, Jie, Zengbo, Lv, Huang, Meifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects B cells Bioflavonoids Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Catechin - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - radiation effects Chemical properties DNA damage DNA Damage - drug effects DNA Damage - radiation effects Down-Regulation - drug effects Flavones Flavonoids Gene Expression Regulation, Neoplastic - drug effects Health aspects Humans Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mediation Radiation Radiation therapy Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology Radiotherapy
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