Cordycepin ameliorates kidney injury by inhibiting gasdermin D‐mediated pyroptosis of renal macrophages through nuclear factor kappa‐B

To explain the effect and mechanism of cordycepin (COR) in resisting acute kidney injury (AKI). Network pharmacology was employed to analyze the correlations between COR, AKI, and pyroptosis, as well as the action target of COR. A mouse model of AKI was established by ischemia reperfusion injury (IR...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2024-09, Vol.38 (9), p.e23824-n/a
Hauptverfasser:	Tang, Zhiling, Zhu, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Cordycepin Cytokines Damage detection Deoxyadenosines - pharmacology Gasdermins Inflammation Injuries Injury analysis Intracellular Signaling Peptides and Proteins - metabolism Ischemia Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL network pharmacology NF-kappa B - metabolism Pharmacology Phosphate-Binding Proteins - metabolism Pyroptosis Pyroptosis - drug effects Renal function Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control
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